Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?

Dolcetti, Riccardo; Carbone, Antonino

doi:10.1186/1750-9378-5-22

Cited by 40 publications

(37 citation statements)

References 26 publications

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“…The presence of this herpesvirus has been variably detected in a broad spectrum of other tumors for which a causal role of EBV seems unlikely. These tumors include also chronic lymphocytic leukemia, yet the authors reviewed data suggesting a possible role of EBV as a direct or microenvironmental progression factor in a fraction of CLL [24]. Leukemia, like other cancers, results from somatic mutations in the DNA.…”

Section: Discussionmentioning

confidence: 99%

The Possible Involvement of Epstein -Barr virus In the Etiology of Leukemia

Elawad¹,

Kafi²

2016

J Med Microb Diagn

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Background: Although considerable brainstorm has been known into Epstein-Barr virus EBV as an important etiologic factor in various tumors, virtually little is known about the relationship between EBV genes and leukemia. The actual cause of Leukemia, which is a serious cancer in Sudan, is still under scrutiny. Controversial hypotheses were proposed suggesting the role of physical as well as chemical and even biological factors as being responsible for Leukemia incidents. We hypothesized that EBV could be involved in the etiology of leukemia. We describe here the results of our attempt to find a possible link between leukemia and EBV.Methods: Real-time Polymerase Chain Reaction assay (q-PCR) has recently been used widely for detection of Cell-free EBVDNA in the plasma of patients with leukemia. To determine the possible correlation between plasma cell-free EBV DNA levels and the leukemia, we studied the plasma EBV DNA levels in patients with leukemia that were presented at Radiation and Isotope Centre Khartoum (RICK), Sudan during therapy. The concentrations of plasma cell-free EBV DNA of 128 leukemic patients, 17 patients with EBV-associated lymphoid malignancies during the course of therapy Burkitt's lymphoma, Hodgkin's disease, Nasopharyngeal carcinoma (NPC) as control positive and 15 healthy controls were determined by using the (q-PCR) assay with the PrimerDesign™ genesig quantification kit. Results:The results revealed that EBV DNA was detectable in a wide range of leukemia patients. Plasma EBV DNA was detected in 33/88 Acute lymphoblastic leukemia (ALL) patients 28/40 Chronic myelogenous leukemia (CML),15/17 patients with EBV-associated lymphoid malignancies, but not in any of 15 healthy control subjects. The median concentration of EBV DNA in leukemia and healthy control groups was 6561.00 and 0.00 copies/ml, respectively. Conclusion:Our findings provided evidence of the involvement of EBV in patients with leukemia. The results suggested that EBV DNA genome encoding the non-glycosylated membrane protein BNRF1 pl43 was observed in a significant proportion of patients with ALL. However, we could not exclude a correlation between these viral infections and later leukemogenesis in childhood ALL in Sudan.

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Section: Discussionmentioning

confidence: 99%

The Possible Involvement of Epstein -Barr virus In the Etiology of Leukemia

Elawad¹,

Kafi²

2016

J Med Microb Diagn

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“…Recently, the presence of single polymorphisms, mutations, defects in processing, allele specific loss of transcription and epigenetic inactivation were shown to influence the expression of key microRNAs involved in CLL pathogenesis and affect the clinical course of disease [6–10]. Furthermore, recent studies suggest that the ability of malignant cells to (i) react to microenvironmental stimuli via B-cell receptor (BCR) signaling, (ii) interact with exosomes and accessory cells, and (iii) respond to the presence of viral microRNAs, can have a pivotal role in CLL onset/progression [11–13]. …”

Section: Characteristics and Outcomes Of Chronic Lymphocytic Leukemiamentioning

confidence: 99%

Novel Mechanisms of Regulation of miRNAs in CLL

et al. 2016

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B-cell chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Although, the molecular alterations leading to CLL onset and progression are still under investigation (specifically, the interplay and exact role of oncogenes and tumor suppressors in CLL pathogenesis). MicroRNAs are small non-coding RNAs that regulate gene expression and are expressed in a tissue specific manner. Deregulation of microRNAs can alter expression levels of genes involved in the development and/or progression of tumors. In CLL, microRNAs can function as oncogenes or tumor suppressors. Here, we review the most recent findings on the role of microRNAs in the onset/progression of CLL, and how this knowledge can be used to identify new biomarkers and targets to treat this leukemia.

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“…Among viral infections, herpes virus reactivation is relatively common, with localized Herpes zoster reported more often than (93) disseminated infections (94)(95)(96). In addition, Epstein-Barr virus (EBV) reactivation is important and has been implicated in Richter's transformation (97).…”

Section: Non-neutropenic Patientsmentioning

confidence: 99%