Epstein–Barr Virus Infection and Gastric Cancer

Chen, Xin Zu; Chen, Hongda; Castro, Felipe A.; Hu, Jian; Brenner, Hermann

doi:10.1097/md.0000000000000792

Cited by 109 publications

(139 citation statements)

References 64 publications

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“…Multiple studies in different parts of the world have found the prevalence of EBV in 5 to 16% of gastric carcinomas, which supports its possible role as an etiologic agent of GC 15 . In Asia, Europe, and the Americas, prevalence of EBV is close to 9% of all GC cases reported 16 .…”

Section: Gastric Cancer Etiology and Risk Factorsmentioning

confidence: 66%

Current Perspectives on Gastric Cancer

Marques-Lespier

González‐Pons

Cruz‐Correa

2016

Gastroenterology Clinics of North America

115

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Synopsis Gastric Cancer (GC) is 3rd leading cause of cancer related death worldwide; only 28.3% of are expected to survive >5 years. Although GC incidence has declined in the US during the last decade, an increase in the incidence of GC has been estimated for 2016. GC risk factors include, male gender, having >60 years, infectious agents such as H. pylori, GC family history, certain occupations, tobacco use, and diet, among others. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type, which has worse prognosis. Although promising chemoprevention agents have been reported to decrease GC risk, none have been implemented into clinical practice to date. Risk assessment and surveillance guidelines have been implemented in Asian countries with high incidence of GC, whereas in the US, only the American Society for Gastrointestinal Endoscopy has recently published guidelines for the screening and management gastric lesions. Importance of diagnosis of GC at an early stage is imperative since 5 year survival rates can approximate 90% in this setting.

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Section: Gastric Cancer Etiology and Risk Factorsmentioning

confidence: 66%

Current Perspectives on Gastric Cancer

Marques-Lespier

González‐Pons

Cruz‐Correa

2016

Gastroenterology Clinics of North America

115

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“…20 The most recent systematic review from 2015 reported the prevalence of EBV based on in situ hybridisation, polymerase chain reaction and serology. 21 The virus was found in 5.0%-17.9% of cancer cells, but all adjacent non-cancer cells were consistently EBV negative. It was postulated that EBV is present in the mucosa before malignant transformation 9 and excessive DNA methylation was proposed as a mechanism.…”

Section: Discussionmentioning

confidence: 98%

Co-infection withHelicobacter pyloriand Epstein–Barr virus in benign upper digestive diseases: An endoscopic and serologic pilot study

Buzás¹,

Konderák²

2015

United European Gastroenterology Journal

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“…Several studies also showed significant association [17,18,19]. However, Mouni [15] indicated that EBV is not an important etiological factor in GC arising in North African populations.…”

Section: Discussionmentioning

confidence: 99%