Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae, Jong-Myon; Kim, Eun Hee

doi:10.5812/archcid.34806

Cited by 7 publications

(7 citation statements)

References 54 publications

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“…In this case-control study, EBV-DNA positivity increased the risk of BC development by about threefold (OR = 3.05). This is similar to two recent meta-analysis that reported that the risk of BC association with EBV infection is 3.84 and 4.74 folds higher as compared to controls (Bae and Kim, 2016;Farahmand et al, 2019).…”

Section: Discussionsupporting

confidence: 91%

Association between Epstein-Barr Virus Gene Polymorphism and Breast Cancer Risk among Egyptian Females

Mashaly

Ghorab

Hegazy

et al. 2022

Asian Pac J Cancer Prev

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Background: Epstein-Barr virus (EBV) has been implicated in the development of breast cancer (BC) since 1995. It is classified into A/B genotypes, C/D subtypes, and F/f variants according to variations in its genome. Aim: To determine the distribution difference of EBV types between BC patients and healthy controls in Egypt and to detect the association between different EBV types and BC characteristics. Methods: Three hundred and sixty-two participants (142 BC patients and 220 controls) were enrolled in this study. All participants were screened for EBV infection by determination of viral-capsid-IgG antibodies in their sera. EBNA-1 gene was detected by PCR in tumor biopsies of seropositive patients and in peripheral blood mononuclear cells of controls. A/B genotyping of EBV was performed by nested-PCR targeting the EBNA-2 gene. C/D subtypes and F/f variants were identified by Restriction fragment length polymorphism at BamHI-I W1/I1 and BamHI-F regions of EBV genome, respectively. Results: Among 362 participants, 300(82.9%) were EBV-seropositive, including 120/142(84.5%) of the BC patients and 180/220(81.8 %) of the controls. EBNA-1 gene was positive in 54(45%) of seropositive BC patients and in 38(21.1%) of seropositive controls. There was a significant association of EBNA-1 gene with breast cancer (OR=3.05, 95%CI=1.84-5.07). Moreover, EBNA-1 gene positivity was significantly associated with the more aggressive tumors. Genotype-A and prototype-F were predominant among patients (90.4%, 100%, respectively) as well as among controls (91.7%, 100%, respectively) with no statistical significant association with BC risk. However, subtype-D was significantly more frequent in patients (95.6%) than in controls (64.7%) and was significantly associated with a higher BC risk as compared to subtype-C (OR=11.7, 95%CI=2.4-57.08). Subtype-D was significantly associated with higher grades tumors (100% among grade III), with progesteron receptor-negative tumors and with HER2-positive tumors (100% for each). The combined genotypes that significantly associated with BC risk were ADF (OR=4.9) and BDF (OR=5.5). Conclusions: Subtype-D of EBV could be the only EBV type implicated in BC development among Egyptian females and associated more with poor prognosis.

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Section: Discussionsupporting

confidence: 91%

Association between Epstein-Barr Virus Gene Polymorphism and Breast Cancer Risk among Egyptian Females

Mashaly

Ghorab

Hegazy

et al. 2022

Asian Pac J Cancer Prev

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“…The exact role that EBV plays in the promotion of benign tumours, and the progression of breast cancer in women is still uncertain, despite several studies showing an association between the virus and this type of malignancy (11). A meta-epidemiological study concluded that EBV infection may increase the risk of breast cancer (1). EBV is known by its capacity to induce cellular growth and alter the tumoural environment (24).…”

Section: Discussionmentioning

confidence: 99%

Lack of association between Epstein–Barr virus and mammary tumours in dogs

López¹,

Suárez

Barato³

et al. 2018

Journal of Veterinary Research

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IntroductionEpstein–Barr virus (EBV) is a γ-herpesvirus associated with various neoplasms in humans and is a probable aetiological agent in breast cancer; however, a causal relationship has not yet been established. Because of the epidemiological and clinicopathological similarities between breast cancer and canine mammary tumours, dogs have been proposed as a valid model for breast cancer.Material and MethodsA total of 47 canine mammary gland tumour tissues were processed by routine histopathological technique with haematoxylin-eosin staining and classified according to the type of neoplasm. DNA was extracted from paraffin-embedded tissues and the EBNA-1 gene and the BamHI-W region specific for EBV were evaluated by nested PCR.ResultsThe histopathological evaluation revealed 2 benign neoplasms, and many carcinomas: 2 in situ, 9 simple, 3 solid, 10 complex, and 21 mixed. One sample was positive for the EBNA-1 gene, while all were negative for the BamHI-W region.ConclusionNo association was found between EBV and mammary tumours in dogs. However, here we report for the first time the presence of an EBV gene sequence in a canine mammary tumour. It is likely that detection of EBV might be affected by the quality and quantity of DNA extracted from paraffin-embedded tissues. Additional studies are necessary to establish any association of EBV with mammary gland cancer in humans and in dogs, which could eventually lead to better public health prevention and control.

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“…Association between EBV and breast cancer have been reported from different parts of the world including Asia [188], Africa [189], and Europe [190], with a prevalence of 30-50%. Subsequently, EBV latency II gene products such as LMP-1, -2, EBNA-, and EBER have been detected in breast cancer cells [102,191,192], and a meta-epidemiological study have also shown that EBV infection was highly associated with the risk of breast cancer development [193].…”

Section: Breast Cancermentioning

confidence: 99%

Epstein Barr Virus Associated Lymphomas and Epithelia Cancers in Humans

Ayee¹,

Ofori²,

Wright³

et al. 2020

J. Cancer

112

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Epstein Barr virus (EBV) is a cosmopolitan oncogenic virus, infecting about 90% of the world's population and it is associated to tumors originating from both epithelia and hematopoietic cells. Transmission of the virus is mainly through oral secretions; however, transmission through organ transplantation and blood transfusion has been reported. In order to evade immune recognition, EBV establishes latent infection in B lymphocytes where it expresses limited sets of proteins called EBV transcription programs (ETPs), including six nuclear antigens (EBNAs), three latent membrane proteins (LMP), and untranslated RNA called EBV encoded RNA (EBER), shown to efficiently transform B cells into lymphoblastic cells. These programs undergo different patterns of expression which determine the occurrence of distinct types of latency in the pathogenesis of a particular tumor. Hematopoietic cell derived tumors include but not limited to Burkitt's lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and natural killer (NK)/T cell lymphoma. EBV undergoes lytic infection in epithelia cells for amplification of the viral particle for transmission where it expresses lytic stage genes. However, for reasons yet to be unveiled, EBV switches from the expression of lytic stage genes to the expression of ETPs in epithelia cells. The expression of the ETPs lead to the transformation of epithelia cells into permanently proliferating cells, resulting in epithelia cell derived malignancies such as nasopharyngeal cancer, gastric cancer, and breast cancer. In this review, we have summarized the current updates on EBV associated epithelial and B cell-derived malignancies, and the role of EBV latency gene products in the pathogenesis of the cancers, and have suggested areas for future studies when considering therapeutic measures

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Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Cited by 7 publications

References 54 publications

Association between Epstein-Barr Virus Gene Polymorphism and Breast Cancer Risk among Egyptian Females

Association between Epstein-Barr Virus Gene Polymorphism and Breast Cancer Risk among Egyptian Females

Lack of association between Epstein–Barr virus and mammary tumours in dogs

Epstein Barr Virus Associated Lymphomas and Epithelia Cancers in Humans

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