1986
DOI: 10.1177/000992288602500412
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Epstein-Barr Virus Infection Associated with Rhabdomyolysis and Acute Renal Failure

Abstract: ACUTE RENAL FAILURE associated with nontraumatic rhabdomyolysis has been well documented in several studies'-' and represents between 5 to 7 percent of the cases of acute renal failure treated at two institutions},2 However, a review of the literature has described only 11 cases of rhabdomyolysis and renal failure in conjunction with viral infections.1,3-12 The majority of documented cases have been associated with Influenza A virus.5-&dquo;,&dquo; There is only one previous case reported in the literature tha… Show more

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Cited by 42 publications
(23 citation statements)
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“…Thirteen of the patients were less than 18 years of age, 4 were less than 6 years old, and the youngest reported was 4 years old. Of the 4 young children, 1 had associated dehydration, shock, and rhabdomyolysis [6], and the other 3 were minimally affected [7]. Renal biopsies were performed in 13 patients; 10 had interstitial nephritis and/or fibrosis while 2 had immune complex glomerulonephritis [5].…”
Section: Discussionmentioning
confidence: 99%
“…Thirteen of the patients were less than 18 years of age, 4 were less than 6 years old, and the youngest reported was 4 years old. Of the 4 young children, 1 had associated dehydration, shock, and rhabdomyolysis [6], and the other 3 were minimally affected [7]. Renal biopsies were performed in 13 patients; 10 had interstitial nephritis and/or fibrosis while 2 had immune complex glomerulonephritis [5].…”
Section: Discussionmentioning
confidence: 99%
“…However, ARF is less common in children with rhabdomyolysis, being reported mostly as single cases or as a small series of patients [11,14,15,16,17,18,19,20,21,22,23]. Several conditions provoking rhabdomyolysis and ARF have been reported in children.…”
Section: Discussionmentioning
confidence: 99%
“…Several conditions provoking rhabdomyolysis and ARF have been reported in children. These include infections such as influenza A virus [11,14,15], Epstein-Barr virus [16], and malaria [17], viper bite [18], diabetic coma [19], hyperthermia and status epileptics [20], sodium valproate intoxication [21], hypernatremia [22,23], and trauma [23]. While the precise mechanisms by which rhabdomyolysis causes renal failure remain unclear, three potential mechanisms are postulated.…”
Section: Discussionmentioning
confidence: 99%
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“…7 The pathogenesis of rhabdomyolysis in the pediatric ambulatory population and the risk of developing ARF are poorly characterized. [9][10][11] Our clinical impression has been that rhabdomyolysis in children is a more benign condition, with only a small risk of ARF. Our study objectives were to establish more clearly the pathogenesis of rhabdomyolysis and the associated rates of ARF in pediatric patients, to establish predictors of ARF in these patients, and to explore the relationship of maximal creatinine levels with fluid and bicarbonate administration.…”
mentioning
confidence: 99%