Epstein–Barr Virus Infection in Cancer

Mundo, Lucia; Leoncini, Lorenzo; Accardi-Gheit, Rosita

doi:10.3390/cancers15184659

Cancers

2023

DOI: 10.3390/cancers15184659

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Epstein–Barr Virus Infection in Cancer

Lucia Mundo,

Lorenzo Leoncini,

Rosita Accardi-Gheit

Abstract: EBV was the first human oncogenic virus identified [...]

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2024

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Cited by 3 publications

References 26 publications

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Serum NF-κB in Epstein–Barr Virus-Related Oropharyngeal Carcinoma Diagnostic Usability

Polz,

Morshed,

Drop

et al. 2024

Cancers

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Early diagnosis and effective therapy are the fundamental challenge for modern oncology. Hence, many researchers focus on the search for new or improved biomarkers. Due to the great importance of nuclear factor kappa B (NF-κB) in physiological and pathological processes, we focused on assessing its usefulness as a biomarker in OPSCC. The purpose of the research presented here was to evaluate the prevalence and the level of NF-κB in the serum of OPSCC patients (ELISA). Serum NF-κB levels were also assessed depending on the degree of histological differentiation of the tumor and TN classification. Additionally, we considered the existence of a correlation between the concentration of NF-κB and EBV antibody titers, viral load and selected MMPs—MMP3 and MMP9. Taken together, the obtained results demonstrated that NF-κB level was significantly higher among patients with EBV-related OPSCC than among those without EBV. In addition, the level of NF-κB was significantly higher in more advanced clinical stages. Moreover, a positive correlation was found between the concentration of NF-κB and the level of selected EBV antibodies, viral load and both tested MMPs. The diagnostic accuracy of NF-κB was confirmed by ROC analysis.

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Serum NF-κB in Epstein–Barr Virus-Related Oropharyngeal Carcinoma Diagnostic Usability

Polz,

Morshed,

Drop

et al. 2024

Cancers

View full text Add to dashboard Cite

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Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status

Sikora,

Kiś,

Stępień

et al. 2024

IJMS

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The relationship between Toll-like receptors (TLRs) and prostate cancer (PCa) is complex due to the presence of the Epstein–Barr virus (EBV) infection, which has been identified as a predisposing factor for some cancers, including PCa. The present study aims to investigate these complex links by examining the levels of selected TLRs and the potential impact of EBV infection on PCa. Therefore, we examined the serum of patients with PCa. The study compared EBV(+) patients to risk groups, the Gleason score (GS), and the T-trait. Additionally, the correlation between TLR and antibody levels was examined. The results indicated that higher levels of TLR-2 and TLR-9 were observed in more advanced PCa. The findings of this study may contribute to a deeper understanding of the role of viral infections in PCa and provide information on future strategies for the diagnosis, prevention, and treatment of these malignancies.

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Immune Modulation by Epstein–Barr Virus Lytic Cycle: Relevance and Implication in Oncogenesis

Todorović,

Ambrosio,

Amedei

2024

Pathogens

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EBV infects more than 90% of people globally, causing lifelong infection. The phases of the EBV life cycle encompass primary infection, latency, and subsequent reactivation or lytic phase. The primary infection usually happens without noticeable symptoms, commonly in early life stages. If it manifests after childhood, it could culminate in infectious mononucleosis. Regarding potential late consequences, EBV is associated with multiple sclerosis, rheumatoid arthritis, chronic active EBV infection, lymphomas, and carcinomas. Previous reports that the lytic phase plays a negligible or merely secondary role in the oncogenesis of EBV-related tumors are steadily losing credibility. The right mechanisms through which the lytic cycle contributes to carcinogenesis are still unclear, but it is now recognized that lytic genes are expressed to some degree in different cancer-type cells, implicating their role here. The lytic infection is a persistent aspect of virus activity, continuously stimulating the immune system. EBV shows different strategies to modulate and avoid the immune system, which is thought to be a key factor in its ability to cause cancer. So, the principal goal of our review is to explore the EBV’s lytic phase contribution to oncogenesis.

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Epstein–Barr Virus Infection in Cancer

Abstract: EBV was the first human oncogenic virus identified [...]

Cited by 3 publications

References 26 publications

Serum NF-κB in Epstein–Barr Virus-Related Oropharyngeal Carcinoma Diagnostic Usability

Serum NF-κB in Epstein–Barr Virus-Related Oropharyngeal Carcinoma Diagnostic Usability

Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status

Immune Modulation by Epstein–Barr Virus Lytic Cycle: Relevance and Implication in Oncogenesis

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