Epstein Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues
Daniel Kirchmeier,
Yun Deng,
Lisa Rieble
et al.
Abstract:Epstein Barr virus (EBV) contributes to around 2% of all tumors worldwide. Simultaneously, more than 90% of healthy human adults persistently carry EBV without clinical symptoms. In most EBV carriers it is thought that virus-induced tumorigenesis is prevented by cell-mediated immunity. Specifically, memory CD8+T cells recognize EBV-infected cells during latent and lytic infection.Using a symptomatic primary infection model, similar to infectious mononucleosis (IM), we found EBV induced CD8+tissue resident memo… Show more
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