Epstein–Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances ATP Production in B Cell Tumors through mTOR and HIF-1α
Ryan Incrocci,
Rosalinda Monroy Del Toro,
Grace Devitt
et al.
Abstract:Epstein–Barr Virus (EBV) exists in a latent state in 90% of the world’s population and is linked to numerous cancers, such as Burkitt’s Lymphoma, Hodgkin’s, and non-Hodgkin’s Lymphoma. One EBV latency protein, latency membrane protein 2A (LMP2A), is expressed in multiple latency phenotypes. LMP2A signaling has been extensively studied and one target of LMP2A is the mammalian target of rapamycin (mTOR). Since mTOR has been linked to reprogramming tumor metabolism and increasing levels of hypoxia-inducible facto… Show more
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