Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women

Seo, Seung‐Woo; Kim, W. H.; Song, Yong Sang; Kim, S. H.; Kim, J. W.; Park, N. H.; Kang, Soon Beom; Lee, H. P.

doi:10.1111/j.1525-1438.2005.15222.x

Cited by 9 publications

(11 citation statements)

References 37 publications

(48 reference statements)

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“…The fact that the EBV/C3d receptor was shown to be expressed in cervical epithelial samples, as well as the clear EBV linkage with epithelium originated tumors, made this hypothesis plausible (15). However, other authors did not reach to the same conclusion, confirming that EBV was acting in cervical tumor pathogenesis (33). The absence of EBV infection in controls and the decline of EBV peak in benign cervical lesions suggest that EBV infection occurs late in cervical oncogenesis.…”

Section: Discussionmentioning

confidence: 88%

“…Therefore, there is a continuing need for the identification of viral and host factors that modulate the risk of disease progression (11). Possible agents included Herpes viruses among which more recently Epstein-Barr Virus (EBV), have been suspected to participate in cervical carcinogenesis (15, 33, 31, 13). For example, latent infection with EBV has been shown to act as a carcinogenic cofactor in several epithelial cell malignancies (38).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients

Kahla¹,

Oueslati²,

Achour³

et al. 2012

Braz. J. Microbiol.

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Infection with high risk Human papillomavirus (HR-HPV) is necessary but not sufficient to cause cervical carcinoma. This study explored whether multiple HR-HPV or coinfection with Epstein-Barr virus (EBV) influence the integration status of HPV16 genome. The presence and typing of HPV in a series of 125 cervical specimens were assessed by polymerase chain reaction (PCR) using the specific primers for the HPV L1 region. As for EBV infection, the viral EBNA1 gene was used for its detection through PCR amplification. Disruption of the HPV E2 gene was assessed by amplification of the entire E2 gene with single set of primers, while E2 transcripts were evaluated by a reverse transcription PCR method (RT-PCR). The overall prevalence of HPVDNA was of 81.8% in cervical cancers versus 26.9% in benign lesions. In HPV positive cases, HPV16 and HPV18 were the most prevalent types, followed by HPV types 33, 31. EBV EBNA1 prevalence was statistically more frequent in cervical carcinomas than in benign lesions (29.5%, vs 9.6%; P=0.01). No viral infection was detected in healthy control women. The uninterrupted E2 gene was correlated with the presence of E2 transcripts originating from the HPV episomal forms. It was observed that integration was more common in HPV18 and EBV coinfection. The presence of EBV caused a five-fold [OR= 5; CI= 1.15-21.8; P = 0.04] increase in the risk of HPV16 genome integration in the host genome. This study indicates that EBV infection is acting as a cofactor for induction of cervical cancer by favoring HPVDNA integration.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients

Kahla¹,

Oueslati²,

Achour³

et al. 2012

Braz. J. Microbiol.

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“…Of note, most studies exploring and reporting EBV positivity in cervical carcinoma used only PCR-based assays ( 65 , 75 – 78 ). One study reported EBV positivity by PCR in CIN3 lesions and cervical carcinoma in 15 and 5.8%, respectively, while ISH RNA (EBER) revealed no EBV positivity (0%) in any of the tested samples ( 79 ). This led the authors to conclude that EBV plays little role in the pathogenesis of cervical carcinoma in their population ( 79 ).…”

Section: Role Of Ebv In Cervical Cancer: Possible Oncogenic Effects Omentioning

confidence: 99%

“…One study reported EBV positivity by PCR in CIN3 lesions and cervical carcinoma in 15 and 5.8%, respectively, while ISH RNA (EBER) revealed no EBV positivity (0%) in any of the tested samples ( 79 ). This led the authors to conclude that EBV plays little role in the pathogenesis of cervical carcinoma in their population ( 79 ). Similarly, another study reported EBV positivity in 40/58% (69%) of cervical carcinoma samples by PCR while immunohistochemistry (LMP1 protein) revealed EBV positivity in only 26% of tested samples ( n = 23) ( 80 ).…”

Section: Role Of Ebv In Cervical Cancer: Possible Oncogenic Effects Omentioning

confidence: 99%

The Role of Epstein–Barr Virus in Cervical Cancer: A Brief Update

et al. 2018

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Epstein–Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including B-cell lymphomas (Burkitt lymphoma, Hodgkin lymphoma, and post-transplant lymphoproliferative disorder), various T-cell/NK lymphoproliferative disorders, nasopharyngeal carcinoma, and gastric carcinoma, respectively. In addition, the presence of EBV has been documented in other cancers including breast, prostate, oral, and salivary gland carcinomas. The presence and role of EBV in cervical cancer and its precursor lesions (CIN) have also been described, but the results from the literature are inconsistent, and the causal role of EBV in cervical cancer pathogenesis has not been established yet. In the present review, we briefly surveyed and critically appraised the current literature on EBV in cervical cancer and its variants (lymphoepithelioma-like carcinoma) as well as its precursor lesions (CIN). In addition, we discussed the possible interactions between EBV and human papilloma virus as well as between EBV and immune checkpoint regulators (PD-L1). Though further studies are needed, the available data suggest a possible causal relationship between EBV and cervical cancer pathogenesis.

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“…The association of HMSN1 with MS has been reported [45,46,47] and it is possible that the trinucleotide expansion increases susceptibility to epithelial tumours or to EBV. Some suggest a link between cervical cancer and EBV infection [48,49] although this is not fully accepted [50]. …”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

Rolls

Giovannoni²,

Constantinescu³

et al. 2009

Eur Neurol

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Background: Multiple sclerosis (MS) and Hodgkin lymphoma (HL) share epidemiologic characteristics suggesting a possible common etiology. Epstein-Barr virus (EBV) is associated with HL, Burkitt lymphoma, some varieties of non-Hodgkin lymphoma (NHL) and nasopharyngeal carcinoma (NPC).Method:Patients were located through MS databases for (a) Barking and Havering, NE London; catchment ∼400,000; MS patient number 751, and (b) Nottingham, catchment ∼2,000,000; MS patient number 1,236. Search was undertaken for lymphoma or NPC and diagnosis of MS verified by McDonald criteria. Results: We identified five UK-born and resident patients of interest: (1) male with onset HL aged 20 years developing relapsing-remitting MS 11 years later; (2) female with severe relapsing-remitting MS whose partner developed NHL, 5 years after MS diagnosis; (3) female with secondary progressive MS beginning at age 38 years who developed NHL 25 years later; (4) female diagnosed with MS aged 19 years who developed HL 4 years later, and (5) female with hereditary motor and sensory neuropathy developing cervical cancer at the age of 32 years, NPC at 33 years, and RR MS at 36 years. Conclusion: Our study supports a possible association between MS, HL, NHL, and perhaps NPC all of which are associated with EBV infection.

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Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women

Cited by 9 publications

References 37 publications

Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients

Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients

The Role of Epstein–Barr Virus in Cervical Cancer: A Brief Update

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

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