Epstein-Barr Virus-related Acute Genital Ulcer Successfully Treated with Colchicine

Nouchi, A.; Monsel, Gentiane; Lafon‐Desmurs, B.; Meng, Laurence; Burrel, Sonia; Moyal‐Barracco, Micheline; Caumes, Éric

doi:10.2340/00015555-2761

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Other research demonstrates the positive effect of colchicine in respiratory syncytial virus replication and suppression of secondary airway inflammation given the promoted expression of IFN-α and IFN-β1 of colchicine and regulation of anti-oxidative factor production [10,11]. In addition, there is a wide range of preclinical and clinical literature on the effect of colchicine inhibiting viral disease like adenoviral and adeno-associated viral [12], herpes simplex virus type 1 [13], Epstein-Barr virus [14], and hepatitis virus [15,16], among others.…”

Section: Dear Editormentioning

confidence: 99%

Colchicine as a possible therapeutic option in COVID-19 infection

et al. 2020

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Section: Dear Editormentioning

confidence: 99%

Colchicine as a possible therapeutic option in COVID-19 infection

et al. 2020

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“…EBV infection has been documented in small‐vessel endothelium and smooth muscle adjacent to the ulcers as well as muscular vessel vasculitis. Vulvar ulceration associated with EBV reactivation has been described, but less clearly defined …”

Section: Pathogenesismentioning

confidence: 99%

“…Primary herpetic vulvovaginitis is probably the most important differential diagnosis in adolescent or young women, which can be clearly excluded by proper laboratory examinations. Several distinct nosological entities may have been reported under this term, while the pathogenesis of the genital ulceration, infectious or reactive, in the presence of primary EBV infection remains unclear . The proposed diagnostic criteria, including five major and two minor criteria, well describe the typical features of clinical manifestations, but fail to cover the whole spectrum of the disease, such as the onset age, sexual experiences and lesional distribution.…”

Section: Nomenclature and Diagnosismentioning

confidence: 99%

“…Vulvar ulceration associated with EBV reactivation has been described, but less clearly defined. 25,26 Primary EBV infection is generally asymptomatic. Two patterns of EBV seroconversion are known: in developed countries of high hygiene standard, the peak is observed in children at 2-4 years and later at 14-18 years, while in countries with lower hygiene standards, the primary EBV infection is usually acquired in early childhood, almost by the age of 6 years.…”

Section: Pathogenesismentioning

confidence: 99%

“…Several distinct nosological entities may have been reported under this term, 30 while the pathogenesis of the genital ulceration, infectious or reactive, in the presence of primary EBV infection remains unclear. 26,29,30 The proposed diagnostic criteria, 30 including five major and two minor Figure 2 The second type of Lipsch€ utz genital ulcer (Abb. 6., Lip-sch€ utz B, 1927), the predominant form, was composed of multiple shallow or deepened ulcers located in vaginal vestibulum, labia minora and labia majora, with well-defined ragged steeply downslanting undermined borders, in the absence of inflammation in the surrounding tissues, and associated with insignificant painfulness but strong tenderness at touch.…”

Section: Nomenclature and Diagnosismentioning

confidence: 99%

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Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Chen

Plewig

2019

Acad Dermatol Venereol

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Since its first description as ulcus vulvae acutum by Benjamin Lipschütz in 1912, the etiopathogenesis of this peculiar genital ulcer remains incompletely understood. In his original description, two different types of genital ulcers were observed and proposed, which were not precisely defined and distinguished in most subsequent reports. The first type is characterized by acute excruciating genital ulcers of first‐time onset with self‐limited non‐recurrent course in association with gravely symptomatic systemic infections, in which a primary Epstein–Barr virus (EBV) infection is later identified to be probably the most common aetiology. The second type of ulcer usually refers to little painful ulcers of unknown etiopathogenesis in the absence of fever or chills and with a slow torpid progression and recurrent nature. Differentiation from idiopathic aphthous ulcers is unclear. The changes of the cervicovaginal microbiota and microbiome in diseased state deserve further clarification. Acute genital ulcers associated with primary EBV infection in women have drawn attention since 1970s, while the corresponding penile ulcers in men were already known in 1950s. First presented in 1973, juvenile gangrenous vasculitis of the scrotum with an acute painful scrotal ulcer preceded by symptomatic pharyngeal infections can be considered as the male counterpart of ulcus vulvae acutum, and the future clinical survey should include primary EBV infection.

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Lipschütz’s acute vulvar ulcer: a systematic review

et al. 2020

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In previously healthy subjects, vulvar ulcers are mostly caused by sexually transmitted microorganisms. Lipschütz's acute vulvar ulceration, first reported in 1912, is a non-sexually acquired condition characterized by sudden onset of a few genital ulcers. We systematically review presentation, underlying causes and disease duration of Lipschütz's ulceration.Comprehensive source of Excerpta Medica, National Library of Medicine and Web of Science databases was performed. Reports including cases of apparently previously healthy females affected by Lipschütz's ulceration were selected a predefined database was used to extract data on demographics, history, clinical and microbiological findings, and treatment.The search disclosed 158 cases. Almost 90% of cases were ≤20 years of age and sexually inactive. Lesions were usually one to about three, painful, ≥10 mm large, well-delimited, with a fibrinous and necrotic center and a symmetric distribution. Voiding disorders and enlarged inguinal lymph nodes were observed in a large subset of cases. Canker sores were noted in 10% of patients. Lipschütz's vulvar ulceration occurred concomitantly with an infectious disease in 139 cases. Infectious mononucleosis syndrome (N=40) was the most frequently detected well-defined infection, followed by mycoplasma species infections (N=11). The disease resolved after ≤3 weeks. CONCLUSIONS: Lipschütz's ulceration mainly affects both sexually inactive and, less frequently, sexually active subjects ≤20 years of age, presents with ≤3 vulvar ulcers, resolves without recurrences within 3 weeks and is temporarily associated with an infection, most frequently a flu-like illness or an infectious mononucleosis syndrome.

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Epstein-Barr Virus-related Acute Genital Ulcer Successfully Treated with Colchicine

Cited by 8 publications

References 12 publications

Colchicine as a possible therapeutic option in COVID-19 infection

Colchicine as a possible therapeutic option in COVID-19 infection

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Lipschütz’s acute vulvar ulcer: a systematic review

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