Equal effects of typical environmental and specific social enrichment on posttraumatic cognitive functioning after fimbria-fornix transection in rats

Gram, Marie Gajhede; Gade, Louise; Wogensen, Elise; Mogensen, Jesper; Malá, Hana

doi:10.1016/j.brainres.2015.10.019

Cited by 7 publications

(4 citation statements)

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“…Previous studies have demonstrated that either the enriched environment or exercise could be promising strategies in enhancing learning and memory as well as upregulation of the BDNF/TrkB signaling pathway, thus highlighting their therapeutic potential [26][27][28]. It has been shown that, compared to a single intervention, combined exercise and enriched environment interventions yield better effects in healthy animals [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

Zhu

et al. 2021

IJERPH

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This study aimed to investigate the effects and potential mechanisms of exercise combined with an enriched environment on learning and memory in rats. Forty healthy male Wistar rats (7 weeks old) were randomly assigned into 4 groups (N = 10 in each group): control (C) group, treadmill exercise (TE) group, enriched environment (EE) group and the TE + EE group. The Morris water maze (MWM) test was used to evaluate the learning and memory ability in all rats after eight weeks of exposure in the different conditions. Moreover, we employed enzyme-linked immunosorbent assay (ELISA) to determine the expression of brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) in the rats. The data showed that the escape latency and the number of platform crossings were significantly better in the TE + EE group compared to the TE, EE or C groups (p < 0.05). In addition, there was upregulation of BDNF and TrkB in rats in the TE + EE group compared to those in the TE, EE or C groups (p < 0.05). Taken together, the data robustly demonstrate that the combination of TE + EE enhances learning and memory ability and upregulates the expression of both BDNF and TrkB in rats. Thus, the BDNF/TrkB signaling pathway might be modulating the effect of exercise and enriched environment in improving learning and memory ability in rats.

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Section: Introductionmentioning

confidence: 99%

Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

Zhu

et al. 2021

IJERPH

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“…Studies have concluded that EE has a more profound effect on cognitive improvement compared to social enrichment (SE) alone following insult or injury, but both SE and EE improve cognition beyond standard housing conditions (SC) (i.e. no form of enrichment) (Gajhede Gram, Gade, Wogensen, Mogensen, & Mala, 2015; Sozda et al, 2010). We have previously shown in young rats that four months of EE, and not SE, is sufficient to improve learning ability and enhance metabotropic glutamate receptor-dependent long-term potentiation (mGluR-LTP) via a mechanism involving activation of p70S6 kinase (p70S6K) in hippocampus (Hullinger et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity

Cortese

Olin

O’Riordan

et al. 2018

Neurobiology of Aging

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Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor-dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we investigated whether 1-month EE is sufficient to improve hippocampus-dependent learning and memory and enhance hippocampal LTP in 23-24 month-old Fischer 344 male rats. Aged rats were housed in environmentally enriched, socially enriched, or standard housing conditions. We find that aged rats exposed to 1-month of EE demonstrate enhanced learning and memory relative to standard housed controls when tested in the Morris water maze and novel object recognition behavioral tasks. Furthermore, we find that environmentally enriched rats perform significantly better than socially enriched or standard housed rats in the radial-arm water maze and display enhanced mGluR5-dependent hippocampal LTP. Enhanced hippocampal function results from activity-dependent increases in the levels of mGluR5, Homer1c, and phospho-p70S6 kinase. These findings demonstrate that a short exposure of EE to aged rats can have significant effects on hippocampal function.

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“…In addition to the aforementioned effects of EE and SE under physiological conditions, both interventions have been demonstrated to have therapeutic effects under pathological conditions. In this regard, both EE and SE induce recovery in various models of central nervous system injury (Berrocal et al, 2007;Gajhede Gram et al, 2015;Lajud et al, 2018). Moreover, EE increases AHN in mouse models of Down syndrome (Chakrabarti et al, 2011;Pons-Espinal et al, 2013), Alzheimer's disease (Levi and Michaelson, 2007;Mirochnic et al, 2009;Valero et al, 2011;Llorens-Martin et al, 2013;Marlatt et al, 2013), Huntington's disease (Lazic et al, 2006), diabetes (Pamidi and Nayak, 2014), ischemia (Rojas et al, 2013), and chronic pain (Zheng et al, 2017), after cranial irradiation (Garbugino et al, 2016), and during physiological aging (Kempermann et al, 1998(Kempermann et al, , 2002Kempermann, 2008Kempermann, , 2015Speisman et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

2020

Frontiers Research Topics

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Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

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Equal effects of typical environmental and specific social enrichment on posttraumatic cognitive functioning after fimbria-fornix transection in rats

Cited by 7 publications

References 68 publications

Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

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