Abstract. We focus here on the water waves problem for uneven bottoms in the long-wave regime, on an unbounded two or three-dimensional domain. In order to derive asymptotic models for this problem, we consider two different regimes of bottom topography, one for small variations in amplitude, and one for strong variations. Starting from the Zakharov formulation of this problem, we rigorously compute the asymptotic expansion of the involved Dirichlet-Neumann operator. Then, following the global strategy introduced by Bona et al. [Arch. Rational Mech. Anal. 178 (2005) 373-410], we derive new symetric asymptotic models for each regime. The solutions of these systems are proved to give good approximations of solutions of the water waves problem. These results hold for solutions that evanesce at infinity as well as for spatially periodic ones.Mathematics Subject Classification. 76B15, 35L55, 35C20, 35Q35.