Equatorial Lens Pigmentation, Myopia, and Retinal Detachment

Delaney, William V.

doi:10.1016/0002-9394(75)90071-9

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…The incidence of retinal detachment in patients with PG has been reported to be slightly higher (7.6–10%) than for PDS 13,66,67 . The higher rate of retinal detachment in PG patients is probably not a consequence of pilocarpine therapy as the incidence of retinal detachment in patients treated with miotics is similar to those not on miotics 13 …”

Section: Pigmentary Glaucomamentioning

confidence: 99%

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Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

176

167

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Pigment dispersion syndrome (PDS) is an interesting condition that can lead to secondary open angle glaucoma. Pigmentary glaucoma is primarily a disease of young people, myopes and men. PDS is characterized by the presence of Krukenberg spindles, iris trans-illumination defects, trabecular meshwork pigmentation and backward bowing of the iris. Posterior bowing of the iris causes rubbing of the pigmented iris epithelium against lens structures, liberation of pigment and trabecular meshwork changes that result in reduced aqueous outflow with the risk of glaucoma. Peripheral laser iridotomy can reverse backward bowing of the iris and may prevent progression of pigmentary glaucoma.

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Section: Pigmentary Glaucomamentioning

confidence: 99%

“…The incidence of retinal detachment in patients with PG has been reported to be slightly higher (7.6-10%) than for PDS. 13,66,67 The higher rate of retinal detachment in PG 870…”

Section: Retinal Detachmentmentioning

confidence: 99%

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

176

167

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“…tion. [8][9][10] Eyes with PDS or PG have roughly a 6% to 7% cumulative lifetime incidence of retinal detachment, irrespective of a history of miotic therapy. 8 The preva-lence of lattice degeneration of the retina appears to be higher for patients with PDS 11 than for the general population with similar amounts of myopia.…”

Section: Methodsmentioning

confidence: 99%

“…Eyes with PDS have a high incidence of retinal detachment [8][9][10] and lattice degeneration. 11,12 Isolated reports 13,14 of patients with PDS and retinal pigment epithelial (RPE) changes have been published.…”

mentioning

confidence: 99%

Retinal Pigment Epithelial Dysfunction in Patients With Pigment Dispersion Syndrome

Greenstein

Seiple²,

Liebmann³

et al. 2001

Arch Ophthalmol

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To test the hypothesis that the retinal pigment epithelial/photoreceptor complex is affected in patients with pigment dispersion syndrome and/or in patients with pigmentary glaucoma.Methods: Electro-oculograms were recorded from patients with pigment dispersion syndrome, pigmentary glaucoma, ocular hypertension, and primary openangle glaucoma and from control subjects. Electrooculograms were recorded during 15 minutes of dark adaptation followed by 15 minutes of light adaptation. For each subject, dark-trough amplitudes, dark-trough latencies, light-peak amplitudes, light-peak latencies, and ratios of the light-peak amplitude to the dark-trough amplitude (Arden ratios) were calculated.Results: A 1-way analysis of variance of the Arden ratios indicated significant differences among the groups of subjects. Results of a post hoc Newman-Keuls test revealed that the mean Arden ratios of patients with pigment dispersion syndrome and patients with pigmentary glaucoma were significantly lower than the mean ratios of the controls, the patients with primary open-angle glaucoma, and those with ocular hypertension. Conclusions:The results provide support for the hypothesis that the integrity of the retinal pigment epithelial/ photoreceptor complex is affected in patients with pigment dispersion syndrome and in those with pigmentary glaucoma. Congenital and/or structural abnormalities of the retinal pigment epithelial/photoreceptor complex should be considered when models of the etiology of pigment dispersion syndrome are proposed.

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“…Pigment dispersion syndrome (PDS) and glaucoma can present with diverse appearance. [ 1 2 3 4 5 6 ] There are multiple theories about the dispersion of pigments in PDS. [ 1 2 3 5 7 ] Pathological findings in PDS were documented in the literature, but very few observations were related to retinal pigment epithelial change.…”

Section: Introductionmentioning

confidence: 99%

Histopathology of Pigment dispersion syndrome and glaucoma

Das

Kuri²,

Tayab³

et al. 2023

Oman Journal of Ophthalmology

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Pigment dispersion syndrome (PDS) can have varied manifestations. Anterior and posterior segment involvement by dispersed pigments was documented in gross pathology and by staining under microscopy. Pigmentary changes in the sclera, cornea, anterior chamber, iris, trabecular meshwork, lens, and retinal pigment epithelium and optic nerve findings were consistent with PDS. External scleral and vitreous pigmentation has never been reported before in the scientific literature. Retinal pigment degeneration and granule dispersion were seen throughout the retina which could be a contributing factor in the etiology of PDS.

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Equatorial Lens Pigmentation, Myopia, and Retinal Detachment

Cited by 13 publications

References 5 publications

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Retinal Pigment Epithelial Dysfunction in Patients With Pigment Dispersion Syndrome

Histopathology of Pigment dispersion syndrome and glaucoma

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