2016
DOI: 10.1016/j.jtbi.2016.10.001
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Equilibria of oligomeric proteins under high pressure – A theoretical description

Abstract: High pressure methods have become a useful tool for studying protein structure and stability. Using them, various physico-chemical processes including protein unfolding, aggregation, oligomer dissociation or enzyme-activity decrease were studied on many different proteins. Oligomeric protein dissociation is a process that can perfectly utilize the potential of high-pressure techniques, as the high pressure shifts the equilibria to higher concentrations making them better observable by spectroscopic methods. Th… Show more

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Cited by 2 publications
(2 citation statements)
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“…The X-ray sample cells being implemented at CHESS are part of a larger toolkit being created by a US National Science Foundation supported Research Coordination Network (RCN) of over two dozen international collaborators interested in high-pressure biology. Other tools being worked on by RCN colleagues include HP-NMR (Peterson & Wand, 2005;Roche et al, 2019;Caro & Wand, 2018;Akasaka, 2015), optical microscopy (Hartmann et al, 2004;Vass et al, 2013;Bourges et al, 2020), methods of growing single-cell organisms in HP environments (Vezzi et al, 2005;Kato, 2006;Takai et al, 2008), tools to facilitate bioinformatic mining of extremophile genomes (Grö tzinger et al, 2014;Black et al, 2013) and molecular dynamics simulations for molecules in HP environments (Ingr et al, 2016;Silva et al, 2015;Garcia & Paschek, 2008;Sarupria et al, 2010;Paschek et al, 2005;Prigozhin et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…The X-ray sample cells being implemented at CHESS are part of a larger toolkit being created by a US National Science Foundation supported Research Coordination Network (RCN) of over two dozen international collaborators interested in high-pressure biology. Other tools being worked on by RCN colleagues include HP-NMR (Peterson & Wand, 2005;Roche et al, 2019;Caro & Wand, 2018;Akasaka, 2015), optical microscopy (Hartmann et al, 2004;Vass et al, 2013;Bourges et al, 2020), methods of growing single-cell organisms in HP environments (Vezzi et al, 2005;Kato, 2006;Takai et al, 2008), tools to facilitate bioinformatic mining of extremophile genomes (Grö tzinger et al, 2014;Black et al, 2013) and molecular dynamics simulations for molecules in HP environments (Ingr et al, 2016;Silva et al, 2015;Garcia & Paschek, 2008;Sarupria et al, 2010;Paschek et al, 2005;Prigozhin et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…The mechanisms of high-pressure adaptation that allow the enzymes of piezophiles to cope with the effects of pressure on the protein conformational landscapes are particularly important for multimeric enzymes. Due to the large positive volume changes inherent to protein-protein interactions [16,36,43,44], pressure commonly induces dissociation of protein oligomers. This dissociation is one of the causes underlying the inhibitory effects of pressure on multimeric enzymes, such as lactate dehydrogenase (LDH), glyceraldehyde-3-phosphate dehydrogenase (GPDH), and malate dehydrogenase (MDH).…”
Section: Introductionmentioning
confidence: 99%