The rapid evolution of the blockchain community has brought together stakeholders from fundamentally different backgrounds: cryptographers, protocol designers, software developers, startup entrepreneurs, corporate executives and investors, academics of various disciplines, and end users. The result is a diverse ecosystem, presently exemplified by the development of a wide range of different blockchain protocols. This raises questions for policy and decision makers: How do different protocols compare? What are their trade-offs? Existing efforts to survey the area reveal a fragmented terminology, and the lack of a unified framework to make the different desirable properties of blockchain protocols explicit.In this paper, we work towards bridging this gap. We evaluate protocols within a five-dimensional design space with the following axes. Optimality: does the protocol achieve its main goals? Stability: are the incentives of its participating agents well-aligned? Efficiency: is its output maximal relative to its use of resources? Robustness: can it cope when its operational assumptions are invalid or perturbed? Persistence: can it recover from catastrophic events? Based on the relevant literature, we organize the properties of existing protocols in subcategories of increasing granularity. The result is a dynamic scheme -termed the PREStO framework. Its scope is to aid the communication between stakeholders of different backgrounds, including managers and investors, and to identify research challenges and opportunities for blockchain protocols in a systematic way. We illustrate this via use cases and make a first step to understand the blockchain ecosystem through a more comprehensive lens.