Equilibrium phase MR angiography of the aortic arch and abdominal vasculature with the blood pool contrast agent CMD-A2-Gd-DOTA in pigs

Kroft, Lucia J.M.; Doornbos, Joost; Benderbous, Soraya; Roos, Albert de

doi:10.1002/(sici)1522-2586(199906)9:6<777::aid-jmri4>3.0.co;2-y

Cited by 17 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, power injectors coupled with automatic triggering allow more accurate timing of gadolinium injections, as seen above [6,10,15]. Second, a new generation of contrast agents (Gdbenzyloxypropionictetraaacetate, Gd-BOPTA) and blood pool agents (BPA) such as ultrasmall particles of iron oxide (USPIO) should be able to revolutionize the use of contrast-enhanced MR angiography in the near future, either by increasing Tl relaxation (Gd-BOPTA and BPA), or by increasing the duration of opacification without concomitant parenchymal enhancement [22,23,24,25,26].…”

Section: Discussionmentioning

confidence: 99%

Effect of contrast dilution on contrast-enhanced MR angiography of the aorta and renal arteries

et al. 2001

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of gadolinium chelate dilution on vascular enhancement in contrast-enhanced two-dimensional (2D) MR subtraction angiography of aorta and renal arteries. Twenty patients were prospectively included. 2D subtraction MR angiography consisted of successive multisection breathhold GRE acquisitions of 16 s (2D FLASH, TR/TE 72/4, flip angle 60 degrees) obtained in the coronal plane before and after intravenous bolus administration of 0.1 mmol/kg BW gadolinium chelate. Patients underwent both diluted and undiluted gadolinium chelate administration in a random order. The data were studied both qualitatively and quantitatively on source and maximum intensity projection images. The length of renal arteries opacified was found not to differ significantly according to contrast dilution. The contrast enhancement percentage was not significantly modified according to the dilution used, but the time to peak enhancement was observed to be longer with the diluted contrast. Qualitatively, the best MR images were those obtained when undiluted contrast was injected first (chi2, P = 0.01). At a dosage of gadolinium chelate 0.1 mmol/kg BW, undiluted contrast 2D MR subtraction angiography seems to be more appropriate for studying diseases of the aorta and renal arteries than a similar diluted dose.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of contrast dilution on contrast-enhanced MR angiography of the aorta and renal arteries

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Potential clinical applications of MMCM, such as CMD-A2-Gd-DOTA, include MR angiography and studies of tissue perfusion and microvascular permeabilities [3,7,8,9,26,27,28]. Using MMCM, a ªblood-body barrierº can be created, similar to the blood-brain barrier, which could differentiate extracerebral pathological processes with distorted microvessels and significant enhancement from normal tissues with intact microvessels and minor enhancement [3,27]; thus, blood-pool agents, such as CMD-A2-Gd-DOTA, can be used to detect ischemia, inflammation and neoplasia with a high sensitivity [7,8,9,10,11,15,27].…”

Section: Discussionmentioning

confidence: 99%

Carboxymethyldextran-A2-Gd-DOTA enhancement patterns in the abdomen and pelvis in an animal model

et al. 2001

View full text Add to dashboard Cite

The aim of this study was to assess MR signal enhancement patterns of carboxymethyldextran (CMD)-A2-Gd-DOTA, a new macromolecular contrast agent, in the abdomen and pelvis of New Zealand white rabbits. Nine New Zealand white rabbits underwent MRI before and following injection of 0.05 mmol/kg body weight (bw) CMD-A2-Gd-DOTA (52.1 kDa), using turbo FLASH-, dynamic FLASH 60 degrees-, T1- and T2-weighted spin-echo and turbo spin-echo sequences up to 10 days p.i. Changes in blood and tissue signal intensities (deltaSI) and relaxation rates (deltaR1) were calculated. Differences between pre- and post-contrast MRI data were compared using the Scheffé test. CMD-A2-Gd-DOTA demonstrated significant blood-pool enhancement and significant tissue enhancement on T1-weighted images, whereas no significant signal changes were observed on T2-weighted images (P < 0.05). Kidney parenchyma, pelvis and bladder demonstrated a subsequent enhancement, resembling renal elimination of the majority of the contrast agent. Liver parenchyma demonstrated a slow, delayed decay of the contrast enhancement due to storage and biodegradation of larger subfractions of the contrast agent. All tissue signal intensities were back to baseline 10 days p.i. CMD-A2-Gd-DOTA is a new macromolecular contrast agent with blood-pool effect, significant signal enhancement of abdominal organs and pelvic bone marrow, partial storage in the liver and baseline tissue signal intensities by 10 days p.i.

show abstract

“…Dextran provides an effective coating for iron‐oxide particles without interfering with the superparamagnetic properties of the nanoparticle. Dextran has an excellent safety profile and has been used in human studies, primarily for MRA (64) and cardiac perfusion studies (65). A number of different iron‐oxide compounds have been developed as MMCM.…”

Section: Ce Imaging Methods For Angiogenesismentioning

confidence: 99%

MRI of tumor angiogenesis

Barrett

Brechbiel

Bernardo

et al. 2007

Magnetic Resonance Imaging

245

197

View full text Add to dashboard Cite

Angiogenesis has long been established as a key element in the pathophysiology of tumor growth and metastasis. Increasingly, new molecularly targeted antiangiogenic drugs are being developed in the fight against cancer. These drugs bring with them a need for an accurate means of diagnosing tumor angiogenesis and monitoring response to treatment. Imaging techniques can offer this in a noninvasive way, while also providing functional information about the tumor. Among the many clinical imaging techniques available, MRI alone can provide relatively good spatial resolution and specificity, without ionizing radiation and with limited side effects. Arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) imaging techniques can be employed to confer indirect measures of angiogenesis, such as blood flow and blood volume, without the need for external contrast agents. Dynamic contrast-enhanced (DCE)-MRI is rapidly emerging as a standard method for directly measuring angiogenesis during angiogenesis-inhibitor drug trials. As macromolecular MR contrast agents become available, they will inevitably be utilized in the assessment of tumor perfusion and vessel permeability. Meanwhile, technological advances have made imaging at a molecular level a possibility. They have brought the potential to directly target MR contrast agents to markers of angiogenesis, such as the ␣ v ␤ 3 integrin. Before this is used clinically, however, substantial gains in sensitivity brought about by improved coils, pulse sequences, and contrast agents will be needed. Herein we discuss the techniques currently available for MRI of angiogenesis, along with their respective advantages and disadvantages, and what the future holds for this evolving field of imaging.

show abstract

Equilibrium phase MR angiography of the aortic arch and abdominal vasculature with the blood pool contrast agent CMD-A2-Gd-DOTA in pigs

Cited by 17 publications

References 31 publications

Effect of contrast dilution on contrast-enhanced MR angiography of the aorta and renal arteries

Effect of contrast dilution on contrast-enhanced MR angiography of the aorta and renal arteries

Carboxymethyldextran-A2-Gd-DOTA enhancement patterns in the abdomen and pelvis in an animal model

MRI of tumor angiogenesis

Contact Info

Product

Resources

About