Equilibrium Solubility Determination, Correlation, and Hansen Solubility Parameters of 2-[4-(Dibutylamino)-2-hydroxybenzoyl] Benzoic Acid in 12 Pure Solvents

Abstract

The solubility of 2-[4-(dibutylamino)-2-hydroxybenzoyl] benzoic acid (BBA) was determined in 12 pure solvents using the static equilibrium method. The measurements were taken at temperatures ranging from 283.15 to 323.15 K. The results indicated a positive relationship between the solubility of BBA and the temperature in the 12 pure solvents, and BBA exhibited the highest solubility in n-propanol and the lowest solubility in nheptane. In addition, the modified Apelblat, Van't Hoff, λh, and Wilson models were used to establish a correlation with the experimental solubility of BBA. The correlation analysis revealed a strong concordance between the experimental and estimated values. Furthermore, the solubility characteristics of BBA were further examined by utilizing Hansen's solubility parameter. The results revealed that the dissolution of BBA in solvents is a multifaceted process, influenced by various parameters rather than solution polarity and HSP. The thermodynamic properties of the mixture of BBA in 12 pure solvents were also evaluated based on the measured solubility data and the parameter values of the Wilson model.