Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter

Abstract

In this study, the solubility data of 18β-glycyrrhetinic acid (GA) in 12 neat solvents were determined by the static equilibrium method at a temperature range of 278.15–323.15 K under a pressure of 0.1 MPa. These selected solvents were methanol, ethanol, n-propanol, isopropanol, methyl acetate, propyl acetate, butyl acetate, isobutyl acetate, acetone, 1,4-dioxane, N,N-dimethylformamide (DMF), and tetrahydrofuran (THF). The experimental results showed that the solubility of GA was positively correlated with temperature and was correlated using thermodynamic models. Activity coefficient models such as the NRTL model, Wilson model, Margules model, and van Laar model were applied to fit the experimental solubility of GA. A good relevance can be obtained for data fitting using these models, and the best fitting effect was achieved with the Wilson equation from ARD and R 2. The Hansen solubility parameter was applied to explain the GA solubility phenomenon in pure solvents. These study results contribute to crystallization operation of GA for purification and separation.

Poly(ionic liquid)s with unique adsorption-swelling ability toward epoxides for efficient atmospheric CO2 conversion under cocatalyst-/metal-/solvent-free conditions

“…8b), the peak intensity of C–O–C stretching vibration (at around 1066 cm −1 ) of styrene oxide interacting with P-[VC6Im]Br-C8-5% slightly decreased, suggesting the strong interaction between P-[VC6Im]Br-C8-5% and styrene oxide. According to the Hansen solubility parameter theory, 40,41,68 solubility parameter ( δ ) can be divided into three parts, a hydrogen-bonding component ( δ H ), a polar component ( δ P ), and a dispersion force component ( δ D ), which is given by δ 2 = δ H 2 + δ P 2 + δ P 2 (Table S2†). The correlation studies between the adsorption-swelling ability ( Q M value) of P-[VC6Im]Br-C8-5% and each component of solubility parameter ( δ H , δ P , and δ D ) showed that the correlation between Q M value and δ H was better than that between Q M value and δ P , and δ D (Fig.…”

“…8b), the peak intensity of C-O-C stretching vibration (at around 1066 cm −1 ) of styrene oxide interacting with P-[VC6Im]Br-C8-5% slightly decreased, suggesting the strong interaction between P-[VC6Im]Br-C8-5% and styrene oxide. According to the Hansen solubility parameter theory, 40,41,68 solubility parameter (δ) can be divided into three parts, a hydrogen-bonding component (δ H ), a polar component (δ P ), and a dispersion force component (δ D ), which is given by δ…”

Equilibrium Solubility of Domiphen Bromide in 12 Mono Solvents: Determination and Correlation

“…The solubility of domiphen bromide in 12 mono solvents (ethanol, n -propanol, n -butanol, 1-pentanol, iso -propanol, iso -butanol, tert -butanol, DMF, DMA, NMP, acetonitrile, and DMSO) was determined by the gravimetric method at temperatures ranging from 283.15 to 323.15 K according to previous studies and the literature. − Excess domiphen bromide and 40 mL of solvent were added into a 120 mL double-jacketed glass container that was connected to a thermostatic water bath (DCW-4006, Shanghai Bilon Instrument Co. Ltd., China). The experimental device is shown in Figure .…”

Exploring the Dissolution Behavior of m-Hydroxybenzoic Acid in 14 Pure Solvents Using Thermodynamic, Molecular Simulation and Hansen Solubility Parameters

“…The parameters (Λ 12 , Λ 21 ) in eq can be calculated from V (pure component molar volume) and Δλ (characteristic energy difference); the model is suitable for calculating the activity coefficients of solutes , and is expressed as eqs –. where the model parameters Δλ 12 and Δλ 21 represent the characteristic energy difference, and their values can be determined by fitting the experimental data to the model . ρ and M represent the density and molar mass.…”

“…where the model parameters Δλ 12 and Δλ 21 represent the characteristic energy difference, and their values can be determined by fitting the experimental data to the model. 36 ρ and M represent the density and molar mass. Molar volume (V) is determined by eq 16 for m-hydroxybenzoic acid and solvents.…”