Equilibrium study and diversified models of drug Norfloxacin in eight pure organic and binary solvents at T = (278.15–328.15) K

Yu, Yemin; Li, Tao; Hu, Yonghong; Yang, Wenge; Zhang, Yuhao; Deng, Renlun; Jiang, Min

doi:10.1016/j.fluid.2016.12.012

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…Throughout the experimental design, the analytical stirred-flask pattern method and the gravity method were used to determine the molar fraction solubility of l -tryptophan. − Different solvents were separately added to eight 10 mL glass test tubes with stoppers (to avoid solvent evaporation during agitation); then, excess l -tryptophan was added to the tubes. The glass tubes were fixed in a glass container filled with water and maintained at a constant temperature by a smart water circulating thermostatic bath system at the temperature range of T = 273.15–333.15 K. The accuracy of system temperature for all of the experiments was under ±0.05 K. Meanwhile, the glass container was placed on a magnetic stirrer, the solvent and the solute were thoroughly stirred and mixed for 12 h to ensure a solid–liquid equilibrium, and finally a supersaturated solution was obtained.…”

Section: Methodsmentioning

confidence: 99%

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

et al. 2019

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In this research, solubility of l-tryptophan in water, methanol, ethanol, acetone, isopropanol, n-butanol, acetonitrile, ethyl acetate, organic pure solvent, and in three binary mixed solvents (water + acetonitrile), (water + methanol), and (water + isopropanol) at the temperature range of T = 278.15–333.15 K was determined with the gravimetric method. The experimental results show that the solubility of l-tryptophan in the above solvents increased as temperature rose, and it achieved the highest dissolution efficiency in water. The improved Apelblat model, the Buchowski–Ksiazaczak λh model, the Redlich–Kister (CNIBS/R–K) model, and the Jouyban–Acree model were used to nonlinearly fit the experimental data of solubility, and the consistency was good. The physicochemical information of l-tryptophan provided in this report may be helpful for its extraction/separation, recrystallization, purification, and formulation development.

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Section: Methodsmentioning

confidence: 99%

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

et al. 2019

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“…The mean deviation (MD) is adopted to describe the deviation from the experimental data and calculated data. where N represents the number of experimental points, and x and x cal represent the experimental and calculated data, respectively. The values of MD, together with the parameters, are listed in Tables – and Tables –.…”

Section: Resultsmentioning

confidence: 99%

Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Buprofezin in Pure and Binary Organic Solvents

Xü

Heng

et al. 2019

J. Chem. Eng. Data

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Buprofezin is a kind of insecticide and an important chemical intermediate product. Data on solid−liquid equilibrium of buprofezin in different solvents is essential for the area of industrial applications. In this work, the solubility of buprofezin in methanol, ethanol, isopropanol, n-butanol, acetonitrile, n-hexane, ethyl acetate, N,N-dimethylformamide, and two binary solvent mixtures (methanol + ethyl acetate and acetonitrile + ethyl acetate) was measured at the temperature range of 278.15−328.15 K at atmospheric pressure by the gravimetric method. The experimental values showed that elevated temperatures increased the solubility of buprofezin in all selected solvents. The modified Apelblat model, the Buchowski− Ksiazaczak λh model, combined nearly ideal binary solvent/Redlich−Kister (CNIBS/R-K) model, Jouyban−Acree model, and an ideal model were used to describe and predict the diversification trend of solubility.

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“…The measurement method (the analytical stirred-flask method and the gravity method) similar to that in the literature is used to measure the solubility of sarafloxacin hydrochloride. − First, add different organic solvents (8 mL) to glass test tubes (10 mL) with stoppers and then add excess sarafloxacin hydrochloride. Place the glass tube in a glass container filled with water and secure it.…”

Section: Methodsmentioning

confidence: 99%

Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Sarafloxacin Hydrochloride in Pure and Binary Organic Solvents from (278.15 to 333.15) K

Cheng

Zhao

Hao³

et al. 2020

J. Chem. Eng. Data

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In this study, the gravimetric method was taken to measure the solubility of the sarafloxacin hydrochloride under atmospheric pressure in methanol, isopropanol, ethanol, 1-butanol, acetonitrile, n-hexane, ethyl acetate, and N,Ndimethylformamide as well as in the (ethyl acetate + acetonitrile), (methanol + nhexane), and (ethyl acetate + n-hexane) mixtures from 278.15 to 333.15 K. The solubility of sarafloxacin hydrochloride increased with increasing temperature in all the solvents. The solid−liquid solubility equilibrium data in the pure and mixed solvents were in apparent agreement with the solubility predicted by the modified Apelblat model, Buchowski−Ksiazaczak λh model, Redlich−Kister (CNIBS/R-K) model, and Jouyban−Acree model. However, the Redlich−Kister (CNIBS/R-K) model best simulated the experimental solubility results.

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Equilibrium study and diversified models of drug Norfloxacin in eight pure organic and binary solvents at T = (278.15–328.15) K

Cited by 10 publications

References 27 publications

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Buprofezin in Pure and Binary Organic Solvents

Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Sarafloxacin Hydrochloride in Pure and Binary Organic Solvents from (278.15 to 333.15) K

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