Equimolar mixture of nitroux oxyde and oxygen during post‐operative physiotherapy in patients with cerebral palsy: A randomized, double‐blind, placebo‐controlled study

Delafontaine, Arnaud; Presedo, Ana; Mohamed, Damir; Lopes, Dolores Ferreira de Melo; Wood, Chantal; Alberti, Corinne

doi:10.1002/ejp.1071

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…However, MT is conducted when the patient is conscious. Pain may be a major obstacle to MT sessions in this population [ 31 , 32 ]. Proper pain management and timely ROM acquisition after surgery can not only improve patients’ satisfaction and quality of life but also reduce the burden on nursing staff and the economic burden of the patient group on health and social care services.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial

Wang,

et al. 2023

Trials

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Background Many patients during manual therapy after anterior ligament reconstruction will experience severe pain, which has a negative impact on their rehabilitation. However, there is rarely an analgesic method for these patients during rehabilitation. Nitrous oxide with rapid analgesic and sedative effects is often used to relieve pain in minor procedures. The purpose of this study is to determine whether or not nitrous oxide analgesia decreases pain compared to oxygen during manual therapy after anterior ligament reconstruction. Methods/design This single-center, randomized, double-blind and controlled trial will recruit 120 patients. Patients ≥ 18 years old undergoing manual therapy after anterior ligament reconstruction (1 month post-operative) with acute pain (VAS ≥ 4) are included. The main exclusion criteria included the following: pulmonary embolism, intestinal obstruction, pneumothorax. Patients will be randomly allocated to the intervention group (A) and the control group (B) in a ratio of 1:1. Doctors, therapists, patients, and data collectors are all blind to the study. The manual therapy will be performed by therapists. Nurses who implemented the intervention handed the doctors envelopes containing the patients’ codes and allocation of A or B. Group A will receive a pre-prepared nitrous oxide/oxygen mixture plus conventional treatment (no analgesic) given as 30-min treatment sessions, once daily, and group B will receive oxygen plus conventional treatment (no analgesic) under the same conditions. Assessments will be taken 2 min before the intervention (T0), 5 min after the beginning of the intervention (T1), and 5 min after the intervention finished (T2). The primary outcome is pain score. Secondary outcomes include vital signs, side effects, joint range of motion, adjuvant analgesia need, therapist and patient satisfaction, and whether willing to receive the same gas again. Expected outcomes We expect nitrous oxide inhalation to have a beneficial effect on the pain of patients who receive manual therapy after anterior ligament reconstruction. Discussion If this treatment appears beneficial, it could improve patients’ satisfaction and quality of life potentially and even be implemented widely in hospital and rehabilitation settings. Trial registration ClinicalTrials.gov identifier, ChiCTR2200061175 (Version 2.0 June 15, 2022), https://www.chictr.org.cn.

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Section: Discussionmentioning

confidence: 99%

“…It is reported that the mixture of 20% N 2 O and 80% O 2 has an equivalent analgesic effect as well as a good sedative effect with 15 mg morphine [ 37 ]. Notably, it does not combine with hemoglobin and is mainly discharged through the lungs with a strong analgesic effect but a weak anesthetic effect [ 31 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial

Wang,

et al. 2023

Trials

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Perspectives and Practice in Eastern and Western Medicine for Pain Management in Rehabilitation Training after Orthopedic Trauma Surgery: A Qualitative Study

Wang,

Jiang

et al. 2024

Pain Management Nursing

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Nitrous oxide provided during intensive physiotherapy for shoulder adhesive capsulitis does not improve function: A randomised controlled trial

Dupeyron,

Dobija,

Castelli

et al. 2024

Annals of Physical and Rehabilitation Medicine

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Equimolar mixture of nitroux oxyde and oxygen during post‐operative physiotherapy in patients with cerebral palsy: A randomized, double‐blind, placebo‐controlled study

Cited by 3 publications

References 45 publications

Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial

Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial

Perspectives and Practice in Eastern and Western Medicine for Pain Management in Rehabilitation Training after Orthopedic Trauma Surgery: A Qualitative Study

Nitrous oxide provided during intensive physiotherapy for shoulder adhesive capsulitis does not improve function: A randomised controlled trial

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