“…Recent studies also focused on the characteristic feature of DAEs and O-acylethanolamines and consistent mixed systems [4,[35][36][37]. Correspondingly, it was shown that lipases can catalyze O -acylation of NAEs to yield DAEs [38] or O -acylation of NAEs can be catalyzed in the presence of fatty acids and acyl-CoA-generating cofactors to produce DAEs [3].…”
“…Recent studies also focused on the characteristic feature of DAEs and O-acylethanolamines and consistent mixed systems [4,[35][36][37]. Correspondingly, it was shown that lipases can catalyze O -acylation of NAEs to yield DAEs [38] or O -acylation of NAEs can be catalyzed in the presence of fatty acids and acyl-CoA-generating cofactors to produce DAEs [3].…”
Acyl chain transfer, which perturbs the protonation equilibrium of amine and reduces the apparent pKa by 2.0-2.5 units, is used to develop a liposome-based drug delivery system.
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