2016
DOI: 10.1152/ajpendo.00362.2015
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Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation

Abstract: Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etiology. Incretin hormones released from the proximal intestine, glucagon-like peptide-1 (GLP-1) and glucose-dependent in… Show more

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Cited by 111 publications
(197 citation statements)
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“…Comparable insulin responses to equivalent doses of D-glucose and commercial grain-based diets have also been demonstrated previously [7]. Although some horses/ ponies will readily consume free glucose, refusal to eat an overly sweet ration may hinder accurate testing in some instances.…”
Section: Discussionsupporting
confidence: 60%
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“…Comparable insulin responses to equivalent doses of D-glucose and commercial grain-based diets have also been demonstrated previously [7]. Although some horses/ ponies will readily consume free glucose, refusal to eat an overly sweet ration may hinder accurate testing in some instances.…”
Section: Discussionsupporting
confidence: 60%
“…tests of insulin sensitivity in ponies may not be as appropriate as oral glucose tests (OGT) that incorporate an assessment of the gastrointestinal system [7]. tests of insulin sensitivity in ponies may not be as appropriate as oral glucose tests (OGT) that incorporate an assessment of the gastrointestinal system [7].…”
Section: Introductionmentioning
confidence: 99%
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