2023
DOI: 10.1007/s11626-023-00800-3
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Equine induced pluripotent stem cells are responsive to inflammatory cytokines before and after differentiation into musculoskeletal cell types

Esther Palomino Lago,
Elizabeth R. Jelbert,
Arabella Baird
et al.

Abstract: Persistent inflammation is associated with the poor regeneration of musculoskeletal tissues. Embryonic stem cells (ESCs) have an attenuated response to inflammatory cytokines, but there are mixed reports on the response of induced pluripotent stem cells (iPSCs) to inflammation. Horses provide a relevant large animal model for studying musculoskeletal tissue diseases and the testing of novel therapies. The aim of this study was to determine if equine iPSCs are responsive to the inflammatory cytokines IL-1β, TNF… Show more

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Cited by 2 publications
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“…We therefore examined the cellular localisation of STAT1 and RUNX2 in either the cells derived from high- and low-risk horses, but no significant differences were observed ( Figure 5 ). Although STAT1 is ubiquitously expressed in both pre- and postosteogenic differentiation, we have previously demonstrated the specificity of the STAT1 antibody to the equine protein [ 57 , 58 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We therefore examined the cellular localisation of STAT1 and RUNX2 in either the cells derived from high- and low-risk horses, but no significant differences were observed ( Figure 5 ). Although STAT1 is ubiquitously expressed in both pre- and postosteogenic differentiation, we have previously demonstrated the specificity of the STAT1 antibody to the equine protein [ 57 , 58 ].…”
Section: Resultsmentioning
confidence: 99%
“…We therefore examined the cellular localisation of STAT1 and RUNX2 in either the cells derived from high-and low-risk horses, but no significant differences were observed (Figure 5). Although STAT1 is ubiquitously expressed in both preand postosteogenic differentiation, we have previously demonstrated the specificity of the STAT1 antibody to the equine protein [57,58]. To identify novel SNPs that may be responsible for the differential expression of STAT1 and COL3A1, we carried out preliminary whole-genome sequencing on two fracture cases and two controls.…”
Section: Candidate Gene Expression Analysis Reveals a Significant Dif...mentioning
confidence: 99%