Equine Inflammatory Markers in the Twenty-First Century

Long, Alicia E.; Nolen-Walston, Rose

doi:10.1016/j.cveq.2019.12.005

“…In a similar way, serum TNF-α increases within 30 minutes, peaks at 60 minutes, and decreases 2-3 hours from endotoxin administration (37,38). Even if studies about SAA in experimentally induced endotoxemic horses are not available, blood SAA concentration is reported to increase up to 1000 times 6 hours after in ammatory stimuli and decrease within 12 hours after stimulus removal (39)(40)(41). It is not known if infection causes an earlier or persistent increase in SAA concentration compared with non-infectious in ammation, but there is evidence that infections are particularly effective in producing strong SAA responses (42), especially in neonatal sepsis (43).…”

Section: Discussionmentioning

confidence: 89%

Serial Measurements of Paraoxonase-1 (PON-1) Activity in Horses with Experimentally Induced Endotoxemia

Scavone

¹

,

Sgorbini

²

,

Borges

³

et al. 2020

Preprint

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Background: Paraoxonase-1 (PON-1) is an antioxidant enzyme, whose activity decreases during the acute phase response in many species. Little is known about PON-1 and its role as a negative acute phase protein during septic inflammation in horses, but promising findings about its utility in diagnosing SIRS and predicting the outcome in diseased horses, were recently highlighted. The objective of the study was to investigate the behaviour of PON-1 in horses after experimentally induced endotoxemia. To this aim, PON-1 activity was measured on 66 plasma samples collected from six clinically healthy mares, previously included in another study, before and at multiple time points between 12 and 240 hours after intravenous infusion of Escherichia coli O55:B5 lipopolysaccharide (LPS). Results: compared with baseline values, a progressive transient decrease of PON-1 activity was observed starting from 24 hours post-infusion, with lowest values observed between 3 to 7 days post-infusion, followed by a normalisation to pre-infusion levels the tenth day. Conclusions: the results of this study suggest that measurement and monitoring of PON-1 activity might be useful to evaluate progression and recovery from endotoxemia in horses. Further studies in horses with naturally occurring sepsis are warranted.

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“…In a similar way, serum TNF-α increases within 30 minutes, peaks at 60 minutes, and decreases 2-3 hours from endotoxin administration (37,38). Even if studies about SAA in experimentally induced endotoxemic horses are not available, blood SAA concentration is reported to increase up to 1000 times 6 hours after in ammatory stimuli and decrease within 12 hours after stimulus removal (39)(40)(41). It is not known if infection causes an earlier or persistent increase in SAA concentration compared with non-infectious in ammation, but there is evidence that infections are particularly effective in producing strong SAA responses (42), especially in neonatal sepsis (43).…”

Section: Discussionmentioning

confidence: 89%

Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia

Scavone

¹

,

Sgorbini

²

,

Borges

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Paraoxonase-1 (PON-1) is an antioxidant enzyme, whose activity decreases during the acute phase response in many species. Little is known about PON-1 and its role as a negative acute phase protein during septic inflammation in horses, but promising findings about its utility in diagnosing SIRS and predicting the outcome in diseased horses, were recently highlighted. The objective of the study was to investigate the behaviour of PON-1 in horses after experimentally induced endotoxemia. To this aim, PON-1 activity was measured on 66 plasma samples collected from six clinically healthy mares, previously included in another study, before and at multiple time points between 12 and 240 hours after intravenous infusion of Escherichia coli O55:B5 lipopolysaccharide (LPS). Results: compared with baseline values, a progressive transient decrease of PON-1 activity was observed starting from 24 hours post-infusion, with lowest values observed between 3 to 7 days post-infusion, followed by a normalisation to pre-infusion levels the tenth day. Conclusions: the results of this study suggest that measurement and monitoring of PON-1 activity might be useful to evaluate progression and recovery from endotoxemia in horses. Further studies in horses with naturally occurring sepsis are warranted.

show abstract

“…In a similar way, serum TNF-α increases within 30 min, peaks at 60 min, and decreases 2–3 h from endotoxin administration [ 37 , 38 ]. Even if studies about SAA in experimentally induced endotoxemic horses are not available, blood SAA concentration is reported to increase up to 1000 times 6 h after inflammatory stimuli and decrease within 12 h after stimulus removal [ 39 – 41 ]. It is not known if infection causes an earlier or persistent increase in SAA concentration compared with non-infectious inflammation, but there is evidence that infections are particularly effective in producing strong SAA responses [ 42 ], especially in neonatal sepsis [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia

Scavone

¹

,

Sgorbini

²

,

Borges

³

et al. 2020

View full text Add to dashboard Cite

Background Paraoxonase-1 (PON-1) is an antioxidant enzyme, whose activity decreases during the acute phase response in many species. Little is known about PON-1 and its role as a negative acute phase protein during septic inflammation in horses, but promising findings about its utility in diagnosing SIRS and predicting the outcome in diseased horses, were recently highlighted. The objective of the study was to investigate the behaviour of PON-1 in horses after experimentally induced endotoxemia. To this aim, PON-1 activity was measured on 66 plasma samples collected from six clinically healthy mares, previously included in another study, before and at multiple time points between 12 and 240 h after intravenous infusion of Escherichia coli O55:B5 lipopolysaccharide (LPS). Results Compared with baseline values, a progressive transient decrease of PON-1 activity was observed starting from 24 h post-infusion, with lowest values observed between 3 to 7 days post-infusion, followed by a normalisation to pre-infusion levels the tenth day. Conclusions The results of this study suggest that measurement and monitoring of PON-1 activity might be useful to evaluate progression and recovery from endotoxemia in horses. Further studies in horses with naturally occurring sepsis are warranted.

show abstract

Equine Inflammatory Markers in the Twenty-First Century

Cited by 34 publications

References 88 publications

Serial Measurements of Paraoxonase-1 (PON-1) Activity in Horses with Experimentally Induced Endotoxemia

Serial Measurements of Paraoxonase-1 (PON-1) Activity in Horses with Experimentally Induced Endotoxemia

Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia

Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia

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