Equine Multinodular Pulmonary Fibrosis and Lymphoma in a Horse Associated with Equine Herpesvirus-5

Bawa, Bhupinder; Werf, Karie Vander; Beard, Laurie A.; Davis, Elizabeth G.; Andrews, Gordon A.; Almes, Kelli

doi:10.1016/j.jevs.2013.11.004

Cited by 11 publications

(6 citation statements)

References 27 publications

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“… 137 More recently, a possible link has been suggested between EHV-5 infection and hematological disorders. Pancytopenia 138 and chronic T-cell leukemia or lymphoma 14 – 17 have been reported. EHV-5 was detected in bone marrow aspirate samples by polymerase chain reaction and typical viral inclusions were observed in infected cells.…”

Section: Ehv-5 Infectionmentioning

confidence: 99%

“… 85 Since then, sporadic occurrences have been diagnosed worldwide. 14 , 17 , 85 , 138 , 141 – 158 On histological examination, there is marked interstitial fibrosis, often with preservation of an “alveolar-like” architecture, lined with cuboidal epithelial cells. The airways contain primarily neutrophils and macrophages, including some macrophages with eosinophilic inclusion bodies in which EHV-5 DNA was identified by in situ hybridization.…”

Section: Ehv-5 Infectionmentioning

confidence: 99%

“… 142 , 146 , 149 , 152 Cases of EMPF associated with leukemia or lymphoma have been reported. 14 , 17 Hypertrophic osteopathy secondary to EMPF has been recorded, even where EHV-5 was not detected. 147 Diagnosis of EMPF is generally made late in the clinical course of the disease, because the clinical signs are initially nonspecific.…”

Section: Ehv-5 Infectionmentioning

confidence: 99%

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Gammaherpesvirus infections in equids: a review

Marenzoni¹,

Stefanetti²,

Danzetta³

et al. 2015

VMRR

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Although the first equine gammaherpesvirus was identified over 50 years ago, the isolation and characterization of other members of this virus group has been relatively recent. Even so, numerous clinical syndromes have been identified in equid species in association with these viruses. Equid gammaherpesviruses are a genetically heterogeneous viral subfamily, the function of which in host immune modulation and disease pathogenesis has not yet been elucidated. While they share similarities with gammaherpesviruses in humans, the role they play in their relationship with the host is the subject of continued interest and research. Their widespread presence in horses and other equid species provides a considerable challenge in linking them with particular clinical and pathological conditions and in defining their significance from a diagnostic and therapeutic viewpoint. The present review provides an update on the taxonomy, epidemiology, and clinical syndromes, especially respiratory, reported in association with gammaherpesvirus infection in horses, donkeys, and other equid species.

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Section: Ehv-5 Infectionmentioning

confidence: 99%

Section: Ehv-5 Infectionmentioning

confidence: 99%

Section: Ehv-5 Infectionmentioning

confidence: 99%

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Gammaherpesvirus infections in equids: a review

Marenzoni¹,

Stefanetti²,

Danzetta³

et al. 2015

VMRR

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“…Equine herpesvirus-5 has been associated with the development of equine multinodular pulmonary fibrosis (EMPF), 51,52 lymphoproliferative disorders, [101][102][103][104] dermatitis, 105 systemic granulomatous disease 106 and ocular disease. 37 Reports of diseases associated with EHV-5 are rare even though shedding of the virus in the equine population is common.…”

Section: Equine Herpesvirus-5mentioning

confidence: 99%

“…122 These findings along with the sporadic nature of EMPF in the equine population suggests that additional host factors such as immunocompetence are important for manifestation of the disease. 29,30,32,62,123 Equine herpesvirus-5 has been detected in several cases with lymphoproliferative disease including lymphoma [101][102][103] and T-cell leukaemia. 104 This mirrors the association between lymphoproliferative disorders in humans and gammaherpesviruses such as the Epstein Barr virus and Kaposi-sarcoma-associated herpesvirus.…”

Section: Equine Herpesvirus-5mentioning

confidence: 99%

Recent advancements in our understanding of equid gammaherpesvirus infections

Easton-Jones

2021

Equine Veterinary Journal

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The reported prevalence is usually higher for EHV-2 infections than EHV-5. Despite being widespread there is still little known about the role of the equine gammaherpesviruses in disease pathogenesis and modulation of the host's immune system. Interpreting the significance of EHV-2 and EHV-5 detection is further complicated by their discovery in immunocompetent horses that do not display associated clinical signs. [1][2][3][4][8][9][10][11][12] Equine gammaherpesviruses are associated with several disease processes but it is currently unclear whether they are the inciting cause of the disease, co-factors or innocent bystanders. Defining their pathogenesis and mechanisms of immune system evasion is central to determining their importance and in formulating suitable therapeutics. This review examines the key challenges currently facing equine gammaherpesvirus research, the recent advancements that have been made in our understanding of the significance and pathogenesis of these viruses and future research directions. | Virus and genome structureThe family Herpesviridae is subdivided into three subfamilies:Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae.EHV-2 and EHV-5 are classified in the genus Percavirus within the Gammaherpesvirinae subfamily. 13 Herpesviruses usually have a narrow host range and are restricted to the order or family to which the natural host belongs. Currently, there are 12 herpesviruses that have the potential to infect equids (Figure 1). The horse is the natural host for five of these viruses (EHV-1, EHV-2, EHV-3, EHV-4 and EHV-5).

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Diseases of the Hemolymphatic and Immune Systems

2017

Veterinary Medicine

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Equine Multinodular Pulmonary Fibrosis and Lymphoma in a Horse Associated with Equine Herpesvirus-5

Cited by 11 publications

References 27 publications

Gammaherpesvirus infections in equids: a review

Gammaherpesvirus infections in equids: a review

Recent advancements in our understanding of equid gammaherpesvirus infections

Diseases of the Hemolymphatic and Immune Systems

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