The current challenges facing agriculture and food systems demand innovations in system design that potentially empower the weakest component in social, economic, and environmental contexts. Recognizing women’s importance in agriculture and food systems, the agroecological business model is one solution for women to gain access to resources (land, finance, credit, etc.), empower their capacity, become entrepreneurs, and improve organic agriculture production and market. This paper focuses on agroecological business models and women’s entrepreneurship in agroecology and sustainable food systems through a scoping review through Google Scholar, Science Direct, and the FAO website. The findings highlight how the co-creation of knowledge between organic producers and female entrepreneurs can increase the efficiency of organic agriculture production. However, women’s entrepreneurship in eco-efficient organic production reinforces participatory guarantee systems, which are crucial for agroecology and sustainable food systems. The conceptual model shows the interdependence between women’s entrepreneurship, organic agriculture production, and food systems through an agroecological business model, which is a key driver for women’s access to resources and guarantees a resilient market for organic agricultural crops. This is a challenging entry point that provides opportunities for co-learning in sustainable food systems that can be shaped for significant positive change. Addressing co-learning food systems through women’s entrepreneurship is an opportunity for all stakeholders to achieve sustainability in food systems. This is critical for those involved in the agroecological transition and the achievement of sustainable development goals.