Equivalent Circuit Implementation of Demyelinated Human Neuron in Spice

A Novel Dual Modeling Method for Characterizing Human Nerve Fiber Activation

“…The values , , and are more commonly represented as conductances, or inverse resistances, and are useful in determining their applicable ionic currents since the difference in potential multiplied by the conductance produces a current. Ohm's law, (1) which can be manipulated to (2) where represents a conductance, is applied at this juncture since it states that the current through a conductor between two points is directly proportional to the potential difference across the two points [18]. , , and represent equilibrium potentials for their respective ions.…”

“…The work of Nathan Soto presented a bulk tissue representation of a human forearm to simulate a nerve conduction velocity (NCV) test in COMSOL as seen in Figure 13 To better represent the human nerve fiber in a SPICE simulation, Nathan Angel presented a dissertation which aimed to model a myelinated/demyelinated HH neuron using the SPICE platform [1]. Angel worked to develop and implement a model of the human nerve in SPICE alone and did not include any work using an FEA tool.…”

“…Specifically Angel worked using SPICE netlist code to develop a library that, when called, would function like a human nerve and output a valid action potential should the instigated stimulus be enough to reach threshold as seen in Figure 15 [1]. Nathan Angel accomplished the work of representing the human nerve in SPICE very accurately and for this reason his SPICE netlist code was originally chosen to be used in this work.…”

“…The attempt at adapting the full HH model to COMSOL's constraints was performed based on the work of Angel [1]. As stated before, Angel developed a library or subcircuit file to be used in conjunction with a source circuit netlist code [1].…”