This paper performed a series of nonlinear response history analyses (NLRHAs) for double-layered domes supported by single-story substructures to investigate the effect of the roof span L of 60m to 150m, yielding story drift ratio θ y , yielding base shear coefficient C y of 0.3 to 0.6, post-yielding stiffness ratio p of 0.01 to 0.5 on the seismic force reduction factor D s and ductility ratio μ. Furthermore, a simple force reduction factor evaluation method considering the resonance between the dome and substructure was proposed. Finally, static analyses with an equivalent seismic load with the proposed D s were compared to the NLRHAs.