ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia

Granzotto, Alberto; McQuade, Amanda; Chadarevian, Jean Paul; Davtyan, Hayk; Sensi, Stefano L.; Parker, Ian; Blurton-Jones, Mathew; Smith, Ian F.

doi:10.1016/j.ceca.2024.102923

Cell Calcium

2024

DOI: 10.1016/j.ceca.2024.102923

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ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia

Alberto Granzotto,

Amanda McQuade,

Jean Paul Chadarevian

et al.

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2024

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Cited by 1 publication

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The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review

Hasan,

Tasnim,

Aktaruzzaman

et al. 2024

Neuroglia

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Microglia, the unique and motile immune cells of the central nervous system (CNS), function as a security guard in maintaining CNS homeostasis, primarily through calcium signaling. The calcium dynamics in microglia control important functions such as phagocytosis, cytokine release, and migration. Calcium dysregulation in microglia has been linked to several CNS disorders, like Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), and ischemic stroke (IS). Calcium entering through channels such as voltage-gated calcium channels (VGCCs), store-operated calcium entry (SOCE), and transient receptor potential (TRP) channels is essential for microglial activation and pro-inflammatory responses. Under pathological conditions, like the formation of amyloid-β plaques in AD, aggregation of α-synuclein in PD, and oxidative stress in MS, calcium dysregulation exacerbates neuroinflammation, mitochondrial dysfunction, and neurodegeneration. Therapeutic strategies targeting calcium signaling pathways, using calcium channel blockers and antioxidant interventions, show promise for alleviating microglial activation and slowing down disease progression. This review summarizes the underlying mechanisms of microglial calcium dysregulation and potential therapeutic benefits for restoring microglial calcium balance in CNS disorders.

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The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review

Hasan,

Tasnim,

Aktaruzzaman

et al. 2024

Neuroglia

View full text Add to dashboard Cite

show abstract

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ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia

Cited by 1 publication

References 74 publications

The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review

The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review

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