2023
DOI: 10.3389/fimmu.2023.1212215
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ER stress: an emerging regulator in GVHD development

Hee-Jin Choi,
Xue-Zhong Yu

Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) is a promising therapeutic option for hematologic malignancies. However, the clinical benefits of allo-HCT are limited by the development of complications including graft-versus-host disease (GVHD). Conditioning regimens, such as chemotherapy and irradiation, which are administered to the patients prior to allo-HCT, can disrupt the endoplasmic reticulum (ER) homeostasis, and induce ER stress in the recipient’s cells. The conditioning regimen activates an… Show more

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