Er:YAG Laser Ablation of Bone in Experimental Diabetics

Akyol, Utkan Kamil; Güngörmüş, Metin

doi:10.1089/pho.2008.2479

Cited by 8 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Burs/drills vs lasers: Evaluation of evidence value in comparative in vivo studies [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] suffers mainly from the wide range of different laser-systems used (Er:YAG, Er,Cr:YSGG, CO2, femtolaser), laser-light delivery (free beam, optic fi bers) and lack of standardized protocols regarding focus-spot energy-density, pulse-rate and pulse-frequency used. There is not even moderate evidence (EV: 0,5, Table 1) for lasers to provide superior cutting performance on micromorphologic, microscopic and clinical level in vivo and most authors point out thermal damages and thermal bonenecrosis in histologic investigations.…”

Section: Group 3 (Experimental Studies In Vivo)mentioning

confidence: 99%

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Troedhan¹,

Mahmoud²,

Wainwright³

et al. 2017

Int J Oral Craniofac Sci

View full text Add to dashboard Cite

Background: New tools for bone-cutting were introduced to oral and maxillofacial surgery in the last decade, such as lasers and piezotomes. Purpose: to evaluate most recent evidence, when surgical procedures performed with drills or burs are compared with laser-and/or piezotome-surgical procedures in experimental and clinical studies and to assess possible advantages of their use in daily practice. Methods: a systematic search of various medical databases with specifi c keywords was performed, excluding studies published before 2006 for their possible invalidity by technological progress. Systematic reviews were assigned to Group 1, experimental studies ex vivo to Group 2, in vivo to Group 3 and clinical studies to Group 4. All studies in each of the groups 2-4 were appraised regarding their evidence, starting with a value of 0 for no evidence of advantages of lasers and/or piezotomes compared to rotary instruments, 1 for moderate evidence with verifi ed clinical impact and 2 for strong evidence and signifi cant clinical impact and statistically processed for their Evidence Value (EV) in each group and their Overall mean Evidence Value (OmEV). Results: 129 studies were fi nally included for evaluation. Two systematic reviews concluded lack of evidence for lasers to be advantageous over burs/drills. Nine reviews for piezotomes reveal strong evidence piezotome-surgery to signifi cantly reduce morbidity and to enhance soft-tissue preservation. Comparative experimental and clinical studies of burs/drills vs lasers revealed a low EV in Group 2 (EV:0,8), Group 3 (EV:0,5) and Group 4 (EV:0,5) with an OmEV of 0,6. Comparative studies burs/drills vs piezotomes resulted in a signifi cant EV in all groups (

show abstract

Section: Group 3 (Experimental Studies In Vivo)mentioning

confidence: 99%

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Troedhan¹,

Mahmoud²,

Wainwright³

et al. 2017

Int J Oral Craniofac Sci

View full text Add to dashboard Cite

show abstract

“…After 10 and 20 days, no significant difference between groups could be found. In a following study, the same group compared bone healing in diabetic rats after ostectomies obtained by Er:YAG laser and bur drilling 122. Applying same laser parameters, the authors did not find any carbonizing effects or collateral damage to surrounding tissue.…”

Section: Experimental Er: Yag Laser Osteotomymentioning

confidence: 93%

Advances in bone surgery: the Er:YAG laser in oral surgery and implant dentistry

Stübinger¹

2010

CCIDE

View full text Add to dashboard Cite

The erbium-doped yttrium aluminium garnet (Er:YAG) laser has emerged as a possible alternative to conventional methods of bone ablation because of its wavelength of 2.94 μm, which coincides with the absorption peak of water. Over the last decades in several experimental and clinical studies, the widespread initial assumption that light amplification for stimulated emission of radiation (laser) osteotomy inevitably provokes profound tissue damage and delayed wound healing has been refuted. In addition, the supposed disadvantage of prolonged osteotomy times could be overcome by modern short-pulsed Er:YAG laser systems. Currently, the limiting factors for a routine application of lasers for bone ablation are mainly technical drawbacks such as missing depth control and a difficult and safe guidance of the laser beam. This article gives a short overview of the development process and current possibilities of noncontact Er:YAG laser osteotomy in oral and implant surgery.

show abstract

“…or intravenously (i.v.) in 0.9% saline, sterile distilled water or citrate buffer (pH 4.5) solutions 53‐60 . A 10% glucose solution is administered 12 h after injection to prevent hypoglycemic shock 50,51 .…”

Section: Current Modelsmentioning

confidence: 99%

“…STZ can be used to induce both T1DM and T2DM, depending on the timing of administration during an animal's development. For T1DM induction, STZ is most commonly administered as a single 50–70 mg/kg intraperitoneal bolus in rats (Wistar, Sprague Dawley [SD]) aged 8–16 weeks following a 12–24 h fast, 53‐59,62‐64 however, doses as low as 30 mg/kg have been used 65 . Intravenous administration is less common but has been used successfully in single doses ranging from 30 to 60 mg/kg 60,66 .…”

Section: Current Modelsmentioning

confidence: 99%

Systemically impaired fracture healing in small animal research: A review of fracture repair models

Ryan

Magony

Gortler

et al. 2021

Journal Orthopaedic Research

View full text Add to dashboard Cite

Fracture healing is a complex process requiring mechanical stability, an osteoconductive matrix, and osteoinductive and osteogenic biology. This intricate process is easily disrupted by various patient factors such as chronic disease and lifestyle. As the medical complexity and age of patients with fractures continue to increase, the importance of developing relevant experimental models is becoming paramount in preclinical research. The objective of this review is to describe the most common small animal models of systemically impaired fracture healing used in the orthopedic literature including osteoporosis, diabetes mellitus, smoking, alcohol use, obesity, and ageing. This review will provide orthopedic researchers with a summary of current models of systemically impaired fracture healing used in small animals and present an overview of the methods of induction for each condition.

show abstract

Er:YAG Laser Ablation of Bone in Experimental Diabetics

Abstract: Histologically, no difference was found between the Er:YAG and bur cavities in diabetic rats regarding bone healing. With these histological and experimental results, we believe that the 2940-nm Er:YAG laser (1.5 W) can be used confidently in the ablation of bones in diabetic cases.

Cited by 8 publications

References 28 publications

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Advances in bone surgery: the Er:YAG laser in oral surgery and implant dentistry

Systemically impaired fracture healing in small animal research: A review of fracture repair models

Contact Info

Product

Resources

About