Background and Objective: Zoon's balanitis (ZB) is an uncommon, benign, idiopathic in¯ammatory condition affecting uncircumcised males. De®nitive treatments include circumcision and carbon dioxide (CO 2 ) laser ablation. We describe an alternative laser modality showing ef®cacy in the treatment of ZB. Study Design/Materials and Methods: We report the ®rst case of ZB effectively treated with Erbium:YAG (Er:YAG) laser ablation. We review the pathogenesis and medical, surgical, and laser management of ZB. Results: Our patient demonstrated a long-term clinical and histologic cure after Er:YAG laser ablation of ZB. Conclusions: As an alternative to circumcision or continuous wave CO 2 laser, we propose a trial of Er:YAG laser ablation as a low risk, ®rst line treatment of ZB. Lasers Surg. Med. 30:123±126, 2002.