Eradicating Mosquitoes using Translocations: a First Field Experiment

Laven, H.; Cousserans, J.; Guille, G.

doi:10.1038/236456a0

Cited by 38 publications

(20 citation statements)

References 7 publications

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“…Recently, LAVEN, COUSSERANS & GUILLE (1972) have shown the prevention of the normal seasonal increase in a small isolated wild population of Culex pipiens following the release of male linked translocation heterozygotes. This was interpreted as the effect of the translocation in causing an initial reduction in density followed by enhanced pressure on the remainder by a constant predator population.…”

Section: Discussionmentioning

confidence: 99%

Controlled crosses and cage experiments with a translocation in Drosophila

Robinson

Curtis

1973

Genetica

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Predictions for the use of autosomal translocations for pest control have been made on the assumptions that translocation heterozygotes are semi-sterile and translocation homozygotes are fully fertile and have viabilities which are either equal to or slightly less than that of the wild type. These parameters were assessed in controlled crosses using a translocation in Drosophila and they showed good agreement with expectation. It was expected that in a mixed population of such translocations and wild types, the karyotype at the higher frequency would be favoured by selection. Two cage experiments were initiated with mixed populations of translocation homozygotes and wild types at a frequency of 9 : 1 in favour of the translocation. Contrary to expectation, the translocation was eliminated from both populations. During this process, there was a reduction in population fertility. Computer studies showed that the results were consistent with a reduction in fitness of the translocation homozygote to about 0.5, i.e. about the same as the semi-sterile heterozygote, so that negative heterosis did not exist and hence frequency dependent selection could not occur.

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Section: Discussionmentioning

confidence: 99%

Controlled crosses and cage experiments with a translocation in Drosophila

Robinson

Curtis

1973

Genetica

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“…Although still at the prototype stage, the RpL14 system is being developed as a potential mechanism for spreading avian malaria ( Plasmodium relictum ) refractory transgenes into invasive populations of Culex quinquefasciatus on Hawaii (F. Reed: personal communication—see “Box 1: Disease-refractory transgenes” section). Due to the reduced viability of heterozygotes, underdominance systems can theoretically cause suppression (Serebrovskii 1940) and have been used to eradicate caged mosquito populations (Laven et al 1972). However, current research is focused on developing them for population replacement strategies and as a means of increasing the confinement of other gene-drive systems (see “Transgene escape” section).…”

Section: Self-sustaining Strategiesmentioning

confidence: 99%

Towards the genetic control of invasive species

2017

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Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in which the mating behaviour of insect pests is exploited to introduce genetically engineered DNA sequences into wild conspecific populations. These ‘transgenes’ work in one or more ways to reduce the damage caused by a particular pest, for example reducing its density, or its ability to vector disease. Although currently being developed for use against economically important insect pests, these technologies would be highly appropriate for application against invasive species that threaten biodiversity. Importantly, these technologies have begun to advance in scope beyond insects to vertebrates, which include some of the world’s worst invasives. Here we review the current state of this rapidly progressing field and, using an established set of eradication criteria, discuss the characteristics which make GPM technologies suitable for application against invasive pests.Electronic supplementary materialThe online version of this article (doi:10.1007/s10530-017-1384-6) contains supplementary material, which is available to authorized users.

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“…However, this paper remained buried until recently, when Laven (196.8) and Curtis (1968a,b) independently revived the hypothesis of using translocations and the ensuing semisterility for mosquito and tsetse fly control, respectively. The applicability of this hypothesis was tested in a cage population by Laven (1969 and later evaluated in a field experiment using Culex pipiens (Laven et al, 1972). A striking reduction in the population size was achieved over a 3-month period following the release of males heterozygous for a sex-linked translocation with approximately 50% sterility.…”

Section: Introductionmentioning

confidence: 98%

SEX-LINKED TRANSLOCATIONS, SEMISTERILITY AND LINKAGE ALTERATIONS IN THE MOSQUITOAEDES AEGYPTI

Bhalla¹

1973

Can. J. Genet. Cytol.

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Seven sex-linked translocations were artificially induced and isolated in the mosquito Aedes aegypti. All translocations have passed through four generations. Each translocation heterozygote shows characteristic sterility with small variation. Egg hatches of the seven translocation heterozygotes ranged from 18% – 71%. Two translocations are TM type, i.e. linked to the M chromosome, and the remaining five are Tm type, i.e. linked to the m chromosome. Possibilities of using both types of translocation for genetic manipulation of field population are discussed. The three linkage groups (I,II,III) have been correlated to the three pairs of chromosomes (1, 2, and 3). For the first time in mosquitoes, translocations have been utilized to correlate a specific gene to a particular segment of a chromosome. The blt locus has been assigned to the small terminal segment distal to the secondary constriction on chromosome 3.

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Eradicating Mosquitoes using Translocations: a First Field Experiment

Cited by 38 publications

References 7 publications

Controlled crosses and cage experiments with a translocation in Drosophila

Controlled crosses and cage experiments with a translocation in Drosophila

Towards the genetic control of invasive species

SEX-LINKED TRANSLOCATIONS, SEMISTERILITY AND LINKAGE ALTERATIONS IN THE MOSQUITOAEDES AEGYPTI

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