Eradication of a resistant Pseudomonas aeruginosa strain after a cluster of infections in a hematology/oncology unit

Gillespie, Thomas; Johnson, Peter; Notman, A.W.; Coia, John; Hanson, Mary

doi:10.1046/j.1469-0691.2000.00051.x

Cited by 35 publications

(16 citation statements)

References 11 publications

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“…However the effect may be short term; one study showed that after 3-6 hours bacterial counts begin to rise again in many household sites, including in sink drain U-tubes [41]. Furthermore, eradication of epidemic strains of P. aeruginosa in hospital settings has in some cases only been achieved by complete replacement of sink drains [42,43], presumably due to higher resistance of P. aeruginosa in biofilms to disinfectants [44].…”

Section: Discussionmentioning

confidence: 99%

Pseudomonas aeruginosa in CF and non-CF homes is found predominantly in drains

Purdy-Gibson

Hundley

Eid

et al. 2015

Journal of Cystic Fibrosis

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Section: Discussionmentioning

confidence: 99%

Pseudomonas aeruginosa in CF and non-CF homes is found predominantly in drains

Purdy-Gibson

Hundley

Eid

et al. 2015

Journal of Cystic Fibrosis

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“…MRPA clones have been isolated in vectors such as bath toys [13] and plumbing circuits [14] in patients suffering from cancer. No vector was identified in our case; however, the epidemic was effectively eradicated once the control measures had been implemented.…”

Section: Discussionmentioning

confidence: 99%

Identifying and controlling a multiresistant pseudomonas aeruginosa outbreak in a latin-american cancer centre and its associated risk factors

Cortés¹,

Cuervo²,

Urdaneta³

et al. 2009

Braz J Infect Dis

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Pseudomonas aeruginosa is an important and frightening microorganism for patients suffering from cancer. Multiresistant P. aeruginosa (MRPA) may appear as a consequence of exposure to multiple antibiotics or from a breakdown in infection control practices. This article reports an MRPA outbreak in a cancer treatment centre and the consequent case control study. Mechanical ventilation was identified as being the main risk factor for developing MRPA colonisation or infection; molecular analysis confirmed the outbreak. A multifaceted strategy was adopted, involving reinforcing hand-washing practices, contact isolation, antibiotic restriction and suction devices for mechanically-ventilated patients. MRPA was controlled and the outbreak ended. Such strategy may be effective in controlling MRPS in low-resource environments amongst high risk cancer patients.

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“…The source of transmission was found to be drains that was detected by molecular profiling to be the only source to harbor KPC, persistently. Outbreak with P. aeruginosa , revealed that patients were not colonized on admittance, but acquired a multi-resistant P. aeruginosa during hospitalization [17]. By running antibiogram and molecular profiling, drains were found to be the only source.…”

Section: Resultsmentioning

confidence: 99%

“…[14] Pseudomonas aeruginosa Sink drainsHematology unit, Lund, SwedenDagens Nyheter [15]ESBL Klebsiella pneumoniae Sink drainsNeurosurgical ICU, Uppsala, SwedenStarlander et al . [5] Klebsiella pneumonia Carbapenem resistantSink drainsICU, Sørlandet, NorwayTofteland et al [16] Pseudomonas aeruginosa DrainsICU, Edinburgh, UKGillespie et al [17]ESBL EnterobacteriaceaeSink drainsICU, Tours, FranceRoux et al [18]Carbapenem-resistant P. aeruginosa Unsealed drainUrology ward, Barcelona, SpainPeña et al [19] P. aeruginosa with unusual antibiogramDrainsNeurosurgery ICU, Clichy, FranceBert et al [20]ESBL Klebsiella oxytoca Sink drainsHospital, Toronto, CanadaLowe et al [21]Foot Mouth Disease virusLeaking drainsCommunity, Pirbright, UKHSE [22] P. aeruginosa Grooved drainage designHaemotology, SingaporeLing and How [23]Carbapenem resistant Klebsiella oxytoca Drainpipes, trapsICU, SpainVergeres -Lopez et al [24]…”

Section: Introductionmentioning

confidence: 99%

Drainage systems, an occluded source of sanitation related outbreaks

Blom¹

2015

Arch Public Health

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BackgroundDrainage systems and its role in sanitation related outbreaks are evident but still occluded once it has been installed. This current review evaluates if drainage systems can cause infections and thus be of clinical concern.MethodA review of the literature was analyzed. Papers, guidelines, and quality management systems have been considered.ResultsAdequate sanitation is fundamental and a prerequisite for safe life and productivity. In contrast, malfunctioning sanitation has been reported to cause outbreaks all over the world. In areas with no sanitation, diarrheal mortality is high and has been shown to decrease by 36% after interventions to improve sanitation. Often, infections are faeces associated and when present in wastewater and sewage sludge poses a high risk of infection upon exposure. Hence, there are working safety guidelines and in industries where infection reduction is essential strict quality assurance systems, i.e. HACCP (hazard analysis critical control points) and GMP (Good Manufacturing Practice) must be complied. Healthcare has recently taken interest in the HACCP system in their efforts to reduce healthcare associated infections as a response to increasing number of ineffective antibiotics and the threat of mortality rate like the pre-antibiotic era. The last few years have called for immediate action to contain the emergence of increasing resistant microorganisms. Resistance is obtained as a result of overuse and misuse of antibiotics in both healthcare and agriculture. Also, by the discharge of antibiotics from manufacturers, healthcare and society. One mechanism of development of novel resistant pathogens has been shown to be by effortless sharing of genetic mobile elements coding for resistance from microbes in the environment to human microbes. These pathogens have been sampled from the drainage systems. These were noticed owing to their possession of an unusual antibiotic resistance profile linking them to the outbreak. Often the cause of sanitation related outbreaks is due to inadequate sanitation and maintenance. However, in general these infections probably go unnoticed.ConclusionDrainage systems and its maintenance, if neglected, could pose a threat in both community and healthcare causing infections as well as emergence of multi-resistant bacteria that could cause unpredictable clinical manifestations.

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Eradication of a resistant Pseudomonas aeruginosa strain after a cluster of infections in a hematology/oncology unit

Cited by 35 publications

References 11 publications

Pseudomonas aeruginosa in CF and non-CF homes is found predominantly in drains

Pseudomonas aeruginosa in CF and non-CF homes is found predominantly in drains

Identifying and controlling a multiresistant pseudomonas aeruginosa outbreak in a latin-american cancer centre and its associated risk factors

Drainage systems, an occluded source of sanitation related outbreaks

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