Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin

Ricevuto, Enrico; Zucca, Emanuele; Mainetti, Carlo; Bertoni, Francesco; Valsangiacomo, Claudio; Pedrinis, E; Borisch, Bettina; Piffaretti, Jean-Claude; Cavalli, Franco; Isaacson, Peter G.

doi:10.1016/s0046-8177(00)80233-6

Cited by 211 publications

(111 citation statements)

References 29 publications

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“…A group from Italy has documented the frequent presence of Chlamydia psittaci in tumor tissue and peripheral blood mononuclear cells (PBMCs) from patients with ocular adnexal lymphomas, although it is important to mention that other data do not support a causative role [107][108][109]. Borrelia burgdorferi infection has been identified in some skin lymphomas, MALT and otherwise [110,111]. A few observational and epidemiologic studies suggest a possible link between hepatitis C virus infection and the development of MALT lymphoma [112][113][114].…”

Section: Nongastric Malt Lymphomamentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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Section: Nongastric Malt Lymphomamentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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“…Borrelia infection has been documented serologically, and Borrelia-specific DNA has been detected by PCR and Southern blot analysis. [4][5][6][7] In addition, antibiotic therapy has been effective in some cases that were positive for B. burgdorferi. 6,7 Interestingly, this association has been reported mainly from Europe, but rarely from the United States.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 99%

“…[4][5][6][7] In addition, antibiotic therapy has been effective in some cases that were positive for B. burgdorferi. 6,7 Interestingly, this association has been reported mainly from Europe, but rarely from the United States. 8,30 We previously reported that such an association is also rare in Asian cases.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 99%

“…Evidence suggesting a link between this lymphoma and Borrelia burgdorferi infection has been reported from many European countries including Germany, and penicillin therapy may cure B. burgdorferiassociated cases. [4][5][6][7] However, this association has not been evident in the United States or Asia. 8,9 API2-MALT1 fusion, resulting from t(11;18) (q21;q21) is specific to MALT lymphoma, and has been found in 10-20% of gastric cases and in up to 50% of pulmonary cases, but is rare in autoimmuneassociated cases.…”

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confidence: 99%

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Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

Takino

et al. 2008

Modern Pathology

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Primary cutaneous marginal zone B-cell lymphoma is considered the cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Although its molecular pathogenesis is currently unknown, an etiological link with Borrelia burgdorferi infection has been identified in European, but not in American or Asian cases. To better understand the pathogenesis and the geographical differences of cutaneous marginal zone B-cell lymphoma, 60 cases from the East Asia, Germany, and the United States at their initial presentation were subjected to the following analyses; (1) clinicopathological comparison between the geographical regions, (2) detection of B. burgdorferi DNA, (3) detection of the API2-MALT1 fusion transcript, a gene alteration specific to mucosa-associated lymphoid tissue lymphoma, and (4) inactivation of tumor suppressor genes (death-associated protein kinase (DAPK), p16 INK4a , p14 ARF , MGMT, TIMP3, CDH1, and RARB) by hypermethylation of the CpG islands. Cases from the three geographical regions showed similar clinicopathological features. However, moderate/marked tissue eosinophilia was found in 9/25 Asian cases, but only 1/23 German cases (P ¼ 0.011) and 0/12 American cases (P ¼ 0.015). All 60 cases were negative for either Borrelia DNA or API2-MALT1 fusion. Tumors from the three regions were highly methylated for DAPK (38-50% of the cases, mean 43%) and p16 INK4a (42-70%, mean 49%), and the positivities were significantly higher than those of nonneoplastic skin (8%, P ¼ 0.0010 and 14%, P ¼ 0.0032, respectively). Methylation of these genes had no significant association with progressive features of the tumor. Primary cutaneous marginal zone B-cell lymphomas from the three geographical regions have common clinicopathological features, however, moderate/marked tissue eosinophilia is a feature found almost exclusively in Asian cases. Borrelia infection and API2-MALT1 fusion are not significant in this tumor. Methylation of DAPK and p16 INK4a genes is a frequent event in this lymphoma at its initial presentation, but may not be associated with tumor progression.

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“…2 Several lines of evidence support the hypothesis that H. pylori can provide the antigenic stimulus to promote and sustain the growth of MALT-type marginal zone B cells in the stomach, first causing acute and chronic gastritis, and subsequently gastric lymphoma 112 (for a recent review, see Sagaert et al 4 ). An increasing number of reports claim a role for various bacterial infections in the development of some minority types of lymphoma, such as Borrelia and skin marginal zone lymphoma 113 and Chlamydia psittaci and ocular adnexal MALT lymphoma. 114,115 Lecuit et al 116 recently reported that the analysis of intestinal tissue obtained from a patient with immunoproliferative small intestinal disease who had a dramatic response to antibiotics revealed the presence of Campylobacter jejuni.…”

Section: Splenic Marginal Zone Lymphomamentioning

confidence: 99%

Lymphoma microenvironment: culprit or innocent?

2007

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Studies are revealing that lymphoid neoplasms are characterized by well-defined chromosome translocations and by the accumulation of subsequent molecular alterations involving mainly the cell cycle and/or apoptotic pathways. However, survival of B and T tumor cells is also dependent on the interactions with the accompanying cells that comprise the lymphoma microenvironment. Although non-tumor cells can contribute both positive and negative signals to the lymphoma cells, in this review we present compelling evidence of the essential influence of the tumor microenvironment on the initiation and progression of specific lymphoma types, highlighting some new therapeutic approaches that target the lymphoma microenvironment.

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Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin

Cited by 211 publications

References 29 publications

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

Lymphoma microenvironment: culprit or innocent?

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