Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian, Saloumeh; Sarchahi, Ali Asghar; Tabrizi, Ali; Derakhshandeh, Abdollah

doi:10.17221/7140-vetmed

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…infections using a PCR assay in 100% and 89% of healthy dogs, respectively, and in 89% and 97.1% of sick dogs, respectively. The find-ings of Hwang et al (2002) and Mirzaeian et al (2013) also support our results. They detected a Helicobacter spp.…”

Section: Discussionsupporting

confidence: 90%

An evaluation of the usefulness of invasive and non-invasive methods used to diagnose Helicobacter spp. infections in dogs

Jankowski¹,

Spużak²,

Kubiak³

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to assess the suitability of invasive and non-invasive methods used to diagnose Helicobacter spp. in the stomachs of dogs. The study was carried out on 30 dogs of both sexes and different breeds, between one and 15 years old. A histopathologic examination, a microbiological culture, a rapid urease test, a direct bacteriological preparation and a nested PCR assay were carried out. Gastric Helicobacter spp. was identified in gastric biopsy specimens from 16 (53.3%) dogs using direct bacteriological preparation, in four (13.3%) dogs based on a culture, in 23 (76.6%) dogs using the rapid urease test and in 21 (70,0%) dogs based on a histopathological assessment of the biopsy specimens. The nested PCR of the gastric biopsy specimens revealed gastric Helicobacter spp. in all the dogs (100%). A saliva PCR assay revealed gastric Helicobacter spp. in 23 (76.6%) dogs, while stool PCR revealed the bacterium in seven (23.3%) dogs. We found that invasive methods were more accurate than non-invasive methods in detecting a Helicobacter spp. infection in dogs. In addition, the nested PCR method used to evaluate the gastric mucosal biopsy specimens was the most accurate test for detecting Helicobacter spp. It was further found that the PCR-based saliva assay was the best non-invasive method for detecting Helicobacter spp. However, taking into consideration that most of the diagnostic methods used to detect this bacterium have drawbacks, at least two diagnostic methods should be used to detect Helicobacter spp. as is done in human medicine.

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Section: Discussionsupporting

confidence: 90%

An evaluation of the usefulness of invasive and non-invasive methods used to diagnose Helicobacter spp. infections in dogs

Jankowski¹,

Spużak²,

Kubiak³

et al. 2017

Polish Journal of Veterinary Sciences

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“…has been associated with gastritis in dogs and cats [89]. The only treatment is a 'triple therapy' composed of two antibiotics and a proton-pump inhibitor [90] but at least in humans this therapy is not always successful and new alternatives are being developed [91]. Some probiotic strains, such as L. casei DN-114 001, showed a high success rate of eradication of Helicobacter in children(along with a standard treatment) at a high daily dosage of 1 Â 10 10 CFU [92].…”

Section: Probiotic Effect On Gut Healthmentioning

confidence: 99%

Microbiota and probiotics in canine and feline welfare

et al. 2015

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Dogs and cats have been cohabiting with us for thousands of years. They are the major human companions. Today, dogs and cats live in urban areas. Cats and most dogs are on high carbohydrate diets and face similar life-style challenges as the human beings. The health and well-being of companion animals, just as their owners, depends on the gut microbes. Providing a proper care and nutritionally balanced diet to companion animals is recognised as a part of our responsibility to maintain the health and well being of our pet. However, as microbiota differences may facilitate exposure to pathogens and harmful environmental influences, it is prudent to search for novel tools to protect dogs and cats and at the same time the human owners from pathogens. Specific probiotic strains and/or their defined combinations may be useful in the canine and feline nutrition, therapy, and care. Probiotic supplementations have been successful in the prevention and treatment of acute gastroenteritis, treatment of IBD, and prevention of allergy in companion animals. New challenges for probiotic applications include maintenance of obesity and overweight, urogenital tract infections, Helicobacter gastritis and parasitic infections. The probiotics of human origin appear to be among the new promising tools for the maintenance of pets' health. However, the host-derived microorganisms might be the most appropriate probiotic source. Therefore, more controlled trials are needed to characterise new and safe probiotic preparations with an impact on general health and well being as well as health maintenance in dogs and cats.

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“…A lack of knowledge about the pathogenicity of Helicobacter infections in both dogs and cats makes treatment decisions difficult. Furthermore, in many veterinary studies, Helicobacter infections have been difficult to eradicate [ 27 , 28 ]. Although many dogs and cats treated with the pharmacological combinations classically used in human medicine did not experience long-term eradication when re-tested, in many of these patients, the frequency of vomiting and the gastric lesion severity improved with therapy.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Teixeira

Filipe²,

Cerqueira

et al. 2022

Veterinary Sciences

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In addition to Helicobacter pylori, many non-Helicobacter pylori Helicobacters (NHPH) are able to cause gastric disease in humans. Cats are a natural reservoir for many of these species. Accordingly, living in close and intimate contact with animals has been identified as a risk factor, and an important zoonotic significance has therefore been attributed to NHPH. To determine the prevalence and associated gastric histopathological changes of Helicobacter species, the gastric mucosa of 71 cats were evaluated. Only four presented normal histopathological mucosa with the absence of spiral-shaped organisms. Normal gastric mucosa and the presence of spiral-shaped bacteria were observed in 13 cats. The remaining animals presented histopathological changes representative of gastritis. Helicobacter species were detected in 53 cats (74.6%) by at least one detection method. None of the animals were positive for H. pylori or for H. ailurogastricus. Helicobacter heilmannii organisms were identified in 20 animals, predominantly in the body gastric region. Helicobacter salomonis was the second most prevalent species (57.1%), although it was mainly found in association with other NHPH. Helicobacter felis and H. bizzozeronii were less frequently detected. The great majority of the Helicobacter spp. PCR-positive animals presented normal features regarding fibrosis/mucosal atrophy, neutrophils, eosinophils, or other inflammatory cells and lymphofollicular hyperplasia. Given the controversy and the strong evidence of absence of significant histopathological alterations associated with the presence of Helicobacter spp. in cats, it is possible to hypothesize that these bacteria may be able to adapt to the feline gastric microenvironment or even to comprise part of the gastric microbiome of this animal species. Thus, prudency must be taken when prescribing an antibiotic therapy based solely on the presence of these bacteria in the feline stomach.

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Eradication of gastric Helicobacter spp. by triple therapy in dogs

Cited by 6 publications

References 26 publications

An evaluation of the usefulness of invasive and non-invasive methods used to diagnose Helicobacter spp. infections in dogs

An evaluation of the usefulness of invasive and non-invasive methods used to diagnose Helicobacter spp. infections in dogs

Microbiota and probiotics in canine and feline welfare

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

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