Eradication of house dust mite from homes of atopic asthmatic subjects: A double-blind trial

Htut, Tin; Higenbottam, Tim; Gill, Gordon W.; Darwin, Sr Ruth; Anderson, Paul B.; Syed, Nasir

doi:10.1067/mai.2001.111240

Cited by 66 publications

(35 citation statements)

References 24 publications

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“…These studies used fundamentally different methods, such as the types of environmental control measures, the sample population, and the form by which results were analyzed. [12][13][14][15][16][17][18][19][20] Most of the studies that showed no difference in the occurrence of symptoms of asthma and allergic rhinitis following environmental hygiene defined environmental control as orientations to reduce household allergens by using mattress covers and other point modifications.…”

Section: Discussionmentioning

confidence: 99%

“…Various published papers had shown that there are variable responses to allergen control measures; the study design and the response assessments, however, varied among these papers, which has generated controversies among physicians. [17][18][19][20][21][22][23][24][25][26][27][28] The purpose of this paper was to discuss the difficulty of controlling allergen exposure and to review various studies in different environments within which individuals spend their days.…”

Section: Introductionmentioning

confidence: 99%

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Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

Segundo

Sopelete

Terra³

et al. 2009

Rev. Bras. Otorrinolaringol.

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The prevalence of allergic diseases such as asthma, rhinitis, allergic conjunctivitis and atopic dermatitis has increased in the last decades. The relationship between allergen exposure, atopic sensitization and development of allergic diseases is widely described in the literature. Aim: To evaluate measures for reducing allergen exposure as part of the treatment of allergic diseases. Methods: An analysis was made of previous studies on allergen exposure done with a similar methodology in the central region of Brazil; the study included homes, hotels, cinemas, cars, taxis, buses and scholar transportation. Results: High levels of Der p 1 and Der f 1 mite allergens were found in a large proportion of the sample in most of the environments included in those studies; there were higher levels of pet allergens in cars and school transportation vehicles. Conclusion: The diversity of allergen exposure demonstrates the need for education about allergic diseases for patients and their families, as well as measures of reducing allergens in homes. This should be part of a global strategy of the management of allergic diseases, given that individuals live in society, not only in their houses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

Segundo

Sopelete

Terra³

et al. 2009

Rev. Bras. Otorrinolaringol.

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“…Despite these problems, some primary avoidance studies have been effective. For example, Nishioka et al, 36 in Murray and Ferguson (1983) 9 1 y Physical barriers 10/10 ++ BHR* Carswell et al (1996) 12 6 mo Physical barriers and Acarosan § 24/25 + PEFR, † BHR Ehnert et al (1992) 3 1 y Physical barriers and tannic acid 8/16 ++ BHR* Van der Heide et al (1997) 10 1 y Physical measures 15/15/15 ++ BHR ‡ Walshaw and Evans (1986) 8 1 y Physical barriers 22/20 ++ PEFR/BHR* Htut et al (2001) 11 12 mo Heat treatment 10/10/10 ++ BHR ‡ BHR, Bronchial hyperreactivity; PEFR, peak expiratory flow rate. *Highly significant improvement.…”

mentioning

confidence: 98%

“…3,7 However, each of those studies reported improvement in asthma symptoms (Table I). 3,[8][9][10][11] From the successful trials, several conclusions about avoidance are possible: first, that effective avoidance is primarily based on physical rather than chemical measures; second, that effective avoidance requires a full regimen in the bedroom; third, that avoidance is only relevant to subjects who are specifically allergic; and finally, that avoidance studies can have a large placebo or Hawthorne effect because patients often change their behavior when they are enrolled in studies of this kind. 7 Given the importance of controlled trials of mite allergen avoidance both to understanding the role of allergen exposure in disease and in designing treatment, it is very disturbing when the New England Journal of Medicine publishes 2 articles that are interpreted as showing that mattress covers are not an effective measure for treating allergic rhinitis or asthma.…”

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confidence: 99%

Allergen avoidance

Platts-Mills

2004

Journal of Allergy and Clinical Immunology

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“…Several physical and chemical control measures for HDM have been described [11][12][13][14]. However, while most studies evaluating the environmental control measures showed a significant reduction in the allergen doses, their clinical effectiveness remains a matter of controversy [15][16][17][18][19]. Therefore, the aim of this study was to determine the effectiveness of physical and chemical environmental control measures for HDM in controlling asthma in asthmatic children who are sensitized to HDM.…”

Section: Introductionmentioning

confidence: 99%

Environmental intervention for house dust mite control in childhood bronchial asthma

El‐Ghitany

El-Salam

2012

Environ Health Prev Med

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Objectives This study was carried out to determine the effectiveness of physical and chemical environmental control measures for house dust mites (HDM) in controlling bronchial asthma in children. Methods A total of 160 asthmatic children who were sensitized to HDM underwent clinical and environmental assessment. The children were randomly allocated into one of four groups according to the intervention (chemical, physical, both chemical and physical, none) and the effectiveness of the intervention was assessed at 8 and 16 weeks. Results The group for which physical control measures were used showed significant improvement in all outcome measures, including mean differences of forced expiratory volume after 1 s (FEV1) and peak expiratory flow rate (PEFR), which were 2.05% and 4.65 l/min, respectively, at the 8-week follow-up evaluation. The percentage of severe asthma decreased from 45 to 22%. Similar results were obtained for the group with both chemical (tannic acid) and physical interventions (p \ 0.05 for all measures). In the group where tannic acid was used as a chemical measure, the number of children with moderate and severe asthma decreased from 15 in each category to 11 and 7, respectively. In the control group, only the mean difference of PEFR (1.62 l/min) was significant after 16 weeks. Despite these promising findings, only the FEV1 was significantly different (p = 0.014) when the four groups were compared. Conclusions Based on these results, we conclude that simple physical control measures have the potential to contribute to the control of asthma symptoms in asthmatic children sensitized to HDM allergen.

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Eradication of house dust mite from homes of atopic asthmatic subjects: A double-blind trial

Cited by 66 publications

References 24 publications

Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

Allergen avoidance

Environmental intervention for house dust mite control in childhood bronchial asthma

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