Eradication of <scp>Helicobacter pylori</scp> may reduce disease severity in rheumatoid arthritis

Zentilin, Patrizia; Seriolo, Bruno; Dulbecco, Pietro; Caratto, Elisa; Iiritano, E.; Fasciolo, D.; Bilardi, C.; Mansi, C.; Testa, Emanuela; Savarino, Vincenzo

doi:10.1046/j.1365-2036.2002.01284.x

Cited by 70 publications

(54 citation statements)

References 21 publications

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“…It has been known to be a causative agent of type B gastritis and may play an important role in increasing the risk for the development of peptic ulcers, mucosa-associated lymphoid tissue (MALT) and gastric cancer [1, 2]. H. pylori infection has also been implicated in the pathogenesis of autoimmune diseases, including chronic thyroiditis, rheumatoid arthritis, Sjögren syndrome and ITP [3, 4]. ITP is a hematologic disorder characterized by autoantibody-mediated platelet destruction.…”

Section: Introductionmentioning

confidence: 99%

Association of Inflammatory Cytokine Gene Polymorphisms with Platelet Recovery in Idiopathic Thrombocytopenic Purpura Patients after the Eradication of Helicobacter pylori

Suzuki¹,

Matsushima²,

Shirakura³

et al. 2008

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Background: Idiopathic thrombocytopenic purpura (ITP) is associated with the cytokine response and dysregulation of the cytokine network. Gene polymorphisms of proinflammatory cytokines are associated with several diseases including ITP. Recently, the successful eradication of Helicobacter pylori has been reported to improve the platelet counts in some patients with ITP. The aim of this study was to elucidate the relationship between cytokine gene polymorphisms and platelet recovery in ITP patients after the eradication of H. pylori. Materials and Methods: Gastric H. pylori infection was confirmed using a culture method or specific IgG antibodies against H. pylori in the serum. Thirty-six adult H. pylori-positive ITP patients received antibiotic therapy for H. pylori. The response to treatment was defined as complete response (CR) if the platelet count was above 150 × 10³/µl and partial response (PR) if the platelet count increased by more than 50 × 10³/µl above the pretreatment count. Genomic DNA was extracted from peripheral blood and polymorphisms in IL-1B (–31, –511), IL-1RN (long or short), TNFA (–308) and TNFB (+252) were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Of the 36 ITP patients, twenty patients (responders) exhibited a platelet response after successful H. pylori eradication therapy, but the other patients (nonresponders) did not. There were no statistical differences in the frequencies of polymorphisms in IL-1B, IL-1RN and TNFA genes between responders and nonresponders. In contrast, the frequency of responders in ITP patients with the TNFB G/G or G/A genotype was significantly higher (69.6%) than that with the TNFB A/A genotype (30.8%). Conclusion: The TNFB (+252) G/G or G/A genotype may therefore be a good predictor of platelet recovery in ITP patients after the eradication of H. pylori.

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Section: Introductionmentioning

confidence: 99%

Association of Inflammatory Cytokine Gene Polymorphisms with Platelet Recovery in Idiopathic Thrombocytopenic Purpura Patients after the Eradication of Helicobacter pylori

Suzuki¹,

Matsushima²,

Shirakura³

et al. 2008

Digestion

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“…Thus, periodontitis may increase systemic inflammation, which may in turn lead to increase RA severity 21 . Likewise Helicobacter pylori infections may contribute to increase RA severity by posing inflammatory burden, while eradication of this bacterium in RA patients improves clinical condition and laboratory markers of RA disease activity 22 .…”

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confidence: 99%

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Susanto

Nesse

Kertia

et al. 2013

Journal of Periodontology

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Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full‐mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age‐, sex‐, and smoking‐matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high‐sensitivity C‐reactive protein (hsCRP), rheumatoid factor, and anti‐citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti‐inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

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“…Previously, H. pylori infected RA patients showed a progressive improvement both in disease activity and laboratory parameters with eradication of H. pylori compared to H. pylori negative patients. In these studies, CRP levels were similar both in H. pylori negative and positive patients at the baseline, but after eradication of H. pylori, it had progressively decreased in RA patients who were H. pylori positive [11,12]. Conversely, no relation between disease activity of RA and eradication of H. pylori was also reported [20].…”

Section: Discussionmentioning

confidence: 78%

“…Besides, H. pylori infection was found to take part in the pathogenesis of Rheumatoid arthritis (RA) [11]. Furthermore, eradication of H. pylori was supported to induce a significant improvement in the disease activity of several chronic inflammatory diseases including RA [12] and chronic idiopathic urticaria [13]. However the relationships between H. pylori infection and disease activity and functional status in patients with AS have not been fully understood yet.…”

mentioning

confidence: 99%

The Impacts of Helicobacter Pylori Antigen Positivity on Ankylosing Spondylitis

İnal¹

2016

Ann Clin Anal Med

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Eradication of Helicobacter pylori may reduce disease severity in rheumatoid arthritis

Cited by 70 publications

References 21 publications

Association of Inflammatory Cytokine Gene Polymorphisms with Platelet Recovery in Idiopathic Thrombocytopenic Purpura Patients after the Eradication of Helicobacter pylori

Association of Inflammatory Cytokine Gene Polymorphisms with Platelet Recovery in Idiopathic Thrombocytopenic Purpura Patients after the Eradication of Helicobacter pylori

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

The Impacts of Helicobacter Pylori Antigen Positivity on Ankylosing Spondylitis

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