In the current study, it was aimed to determine the extent to which adolescents’ levels of hope, self-efficacy and self-esteem predict their career anxiety. To this end, the relational survey model was used to determine the relationship between the variables. The study group was formed by using the convenience sampling method. The online form prepared by the researchers was shared on social media platforms commonly used by adolescents and in this way, a total of 253 adolescents (165 females and 88 males) were reached. The mean age of the participants is 15.61. The data in the study were collected by using a demographic information form developed by the researchers, the Career Anxiety Scale, the Dispositional Hope Scale, the Self-Efficacy Scale for Children and the Rosenberg Self-Esteem Scale. In the analysis of the data, multiple linear regression analysis and the Pearson product moment correlation coefficient were used to determine the relationship between the variables. As a result of the study, negative significant correlations were found between the career anxiety of the adolescents and their levels of hope, self-efficacy and self-esteem. In addition, it was concluded that the career anxiety of the adolescents was predicted negatively and significantly by their hope, self-efficacy and self-esteem. On the basis of these findings, it can be said that the healing power of hope, self-efficacy and self-esteem can be used to cope with the career anxiety of adolescents. The results were discussed in light of the relevant literature and suggestions were made for future research.