Erasmus Syndrome: Co-existence of silicosis and progressive systemic sclerosis in a 55 year old male

Salt-and-pepper dyspigmentation with groove sign in Erasmus syndrome: A double jeopardy

“…This leads to stimulation of collagen synthesis, sclerosis, vasculopathy, and pulmonary fibrosis. [ 2 ] The pathogenesis of salt-and-pepper dyspigmentation in systemic sclerosis is melanocyte destruction with retention of perifollicular melanogenesis due to a rich capillary network. The groove sign arises due to a relative split between the epidermis and dermis along the superficial veins secondary to dermal fibrosis.…”