Eravacycline, the First and Unique Fluorocycline Antibacterial Agent

Abstract

in medical history (1). However, antibiotic resistance is becoming a major global health issue (2). Despite the popular notion that antibiotic exposure is limited to the modern "antibiotic era," the researcher has discovered traces of exposed tetracycline in human skeletal remains dating back to 350-550 CE in ancient Sudanese Nubia (1,3,4). Nevertheless, in the modern era, after its discovery in the 1940s, tetracycline has taken a special place because of its antibacterial activity against many life-threatening microorganisms (5,6).Chlortetracycline was the first tetracycline discovered by the American Cyanamide Company in the 1940s and it is a natural tetracycline isolated from Streptomyces aureofaciens (4-6). Its effectiveness against various pathogens, such as Actinomycetes, Escherichia coli, Mycoplasma spp., and Rickettsiae has solidified its place as a key antibiotics in the