2014
DOI: 10.1073/pnas.1320350111
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Erbin is a negative modulator of cardiac hypertrophy

Abstract: ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart. However, its physiological role in the heart has not been explored. In the present work, we elucidated the role of Erbin in cardiac hypertrophy. Cardiac hypertrophy was induced in mice either by isoproterenol administration or by aortic constriction. The level of Erbin was significantly decreased… Show more

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Cited by 30 publications
(34 citation statements)
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“…Interestingly, the ERBB2 hypomorphic cardiac phenotype observed highlights a pivotal role for ERBB2 in the regulation of physiological cardiac hypertrophy, since the loss of this protein attenuated physiological but not pathological heart growth. This result is in accordance with a recent observation that Erbin, a binding partner of ERBB2, is important for compensated hypertrophy (25). Together, our results demonstrate an ongoing requirement for ERBB2 in adult myocardium to maintain homeostasis.…”
Section: Discussionsupporting
confidence: 93%
“…Interestingly, the ERBB2 hypomorphic cardiac phenotype observed highlights a pivotal role for ERBB2 in the regulation of physiological cardiac hypertrophy, since the loss of this protein attenuated physiological but not pathological heart growth. This result is in accordance with a recent observation that Erbin, a binding partner of ERBB2, is important for compensated hypertrophy (25). Together, our results demonstrate an ongoing requirement for ERBB2 in adult myocardium to maintain homeostasis.…”
Section: Discussionsupporting
confidence: 93%
“…We have previously described roles for both MITF and Erbin in cardiac hypertrophy and heart failure [8, 10]. In the current work, we have demonstrated opposing functions of MITF, which activates Erbin expression in the basal state, but represses Erbin expression during cardiac hypertrophy.…”
Section: Discussionsupporting
confidence: 58%
“…The expression of only 25 genes was similarly changed in the compared gene array (Table S1). Erbin was chosen for further analysis since we have previously shown its involvement in cardiac hypertrophy [10]. …”
Section: Resultsmentioning
confidence: 99%
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