Erbium fractional laser irradiation combined with autologous platelet‐rich plasma and platelet‐poor plasma application for facial rejuvenation

Abstract

Background Erbium fractional laser treatment has immense skin rejuvenation effects, but it is associated with side effects such as erythema and pigmentation. Platelet‐rich plasma (PRP) can enhance the restorative effects of Erbium fractional laser, but there are few studies on this combined treatment in the Asian population, and no study has examined the effects of adding platelet‐poor plasma (PPP) to the combination. Objective This study aims to investigate the effects and safety of Erbium fractional laser irradiation combined with autologous PRP and PPP therapy for facial rejuvenation. Methods Between January 2010 and June 2016, 158 patients with facial skin aging were treated by Erbium fractional laser irradiation combined with autologous PRP and PPP. After three sessions, patients and experienced physicians evaluated the effectiveness of the treatment. Results The symptoms of skin aging, especially skin color, pore expansion, and skin texture, showed obvious improvement after the treatment, according to the evaluation of the patients and the physicians, who reported a total treatment effectiveness rate of 90.51% and 88.61%, respectively. The treatment was well‐tolerated by all the participants, and no hyperpigmentation or depigmentation was observed in any of the cases. The reported side effects were edema (1‐3 days), erythema (2‐4 days), and crusting (3‐10 days). Conclusion Erbium fractional laser irradiation combined with PRP and PPP application is an effective and safe approach for improving facial skin aging and has minimal side effects. Future investigations on a bigger sample with a longer follow‐up period should focus on optimizing the treatment protocol and settings.

Facial rejuvenation by microneedling with irradiated amniotic collagen matrix compared to platelet rich plasma

“…These results were in accordance with other studies 24–26 . Du and Lei, 24 injected PRP on the right sides of the faces of their patients and on the left side an equal amount of normal saline was injected as a negative control.…”

“…Cai et al 26 included 158 patients with facial skin aging. They investigated the efficacy of Erbium fractional laser combined with PRP and PPP therapy for rejuvenation of the face with minimal side effects.…”

“…These results were in accordance with other studies. [24][25][26] Du and Lei, 24 injected PRP on the right sides of the faces of their patients and on the left side an equal amount of normal saline was injected as a negative control. They concluded that treatment with PRP increase thickness of the skin, enhance collagen formation and reduce pigmentation.…”

Trichoscopy as an evaluation method for alopecia areata treatment: A comparative study

“…6-8 However, success rates vary, and local cutaneous atrophy and telangiectasia are common adverse effects. 9Platelet-rich plasma (PRP) has gained much ground, in several medical fields including dermatology and plastic surgery, because of its ability to promote wound healing, 10 its skin rejuvenating effects, 11 and its ability to promote hair growth. 12,13…”

Clinical Efficacy and Safety of Pulsed Dye Laser Combined with Pingyangmycin on Hyperplastic Scar after Acne

“…In the treatment area, water molecules absorb the laser light and produce a thermal energy response that spreads further in the cortex, activating keratinocytes to repair damaged epidermis [ 27 ]. Moreover, the thermal effect can promote the formation of neocollagen in the dermis and further promote the repair of scars [ 28 ]. In the erbium fractional laser therapy, water is utilized to treat the target tissue.…”