ERCC1 haplotypes modify bladder cancer risk: A case–control study

Ricceri, Fulvio; Guarrera, Simonetta; Sacerdote, Carlotta; Allione, Alessandra; Fontana, Dario; Destefanis, Paolo; Tizzani, A; Casetta, G; Cucchiarale, Giuseppina; Víneis, Paolo; Matullo, Giuseppe

doi:10.1016/j.dnarep.2009.12.002

Cited by 30 publications

(25 citation statements)

References 40 publications

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“…For XRCC1 Pro206Pro, one single SNP analysis found a significantly increased risk of bladder cancer for G-allele carriers of XRCC1 Pro206Pro (OR = 1.55, 95% CI = 1.02-2.37 for dominant model) in a Caucasian Italian population (Ricceri et al, 2010). Our previous results suggested that XRCC1 Pro206Pro or the haplotype including the minor allele may contribute to genetic susceptibility for lung cancer (Yin et al, 2007(Yin et al, , 2009b and haplotypes of nine SNPs encompassing XRCC1 Pro206Pro on chromosome 19q13.2-3 were associated with risk of lung cancer (Yin et al, 2008) in a Chinese population and among nonsmoking Chinese women.…”

Section: Discussionmentioning

confidence: 98%

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

Yin

Wang

Liang

et al. 2012

Gene

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Section: Discussionmentioning

confidence: 98%

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

Yin

Wang

Liang

et al. 2012

Gene

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“…This SNP has been associated with response to treatment of lung cancer [46], but not with colorectal cancer [59]. On the other hand, a study of some authors of this paper showed that not only the ERCC1 N118N, but also ERCC1 haplotypes modify bladder cancer risk [47].…”

Section: Discussionmentioning

confidence: 99%

“…Both XRCC1 R399Q and ERCC1 N118N have been found associated with cancer in different studies [41][42][43][44][45][46][47]. The combination of ERCC1 and XRCC1 polymorphisms better predicts clinical outcome to oxaliplatin-based chemotherapy in metastatic colorectal cancer [48].…”

Section: Discussionmentioning

confidence: 99%

XRCC1 and ERCC1 variants modify malignant mesothelioma risk: A case–control study

Betti

Ferrante

Padoan

et al. 2011

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…Through literature search and selection based on the inclusion criteria, 39 studies were found, but only 22 studies met our inclusion criteria, as listed in Table 1. Seventeen studies were excluded for the following reasons: five studies did not contain exact genotype distribution information; (17)(18)(19)(20)(21) four studies were reviews; (22)(23)(24)(25) four studies were not case-control studies; (26)(27)(28)(29) and in three studies, (30)(31)(32) genotype distributions in control population deviated from the Hardy-Weinberg equilibrium. Furthermore, one study of bladder cancer (33) in which the variant allele frequency was extremely lower than expected, which may reflect wrong allele counting or poor genotyping quality, was also excluded from our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

et al. 2010

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Several studies have investigated the associations between X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and the susceptibility to lung cancer and bladder cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 22 case control studies, including 2976 cases and 4495 controls for lung cancer, and 3445 cases and 4599 controls for bladder cancer, met the inclusion criteria and were selected. Overall, there was no evidence showing a significant association between XRCC3 Thr241Met polymorphism and lung cancer risk. Furthermore, the results for bladder cancer showed that significant decreased risk was found for the additive model (odds ratio [OR] = 0.959, 95% confidence interval [CI], 0.924-0.996) and dominant model (OR = 0.982, 95% CI, 0.963-1.000) but not for the recessive model (OR = 0.958, 95% CI, 0.905-1.014). In summary, our meta-analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer. (Cancer Sci 2010; 101: 1777-1782 L ung cancer is one of the most common cancers worldwide, and it is the leading cause of cancer-related deaths in the world.(1) The role of genetic susceptibility in lung cancer has shown that the relatives of patients with lung cancer had an increased risk of the disease.(1,2) Only a fraction of smokers and a low number of non-smokers develop lung cancer, which implies influence of host factors in individual susceptibility. This inter-individual difference in susceptibility may be attributed to genetic polymorphisms in critical genes, including those involved in DNA repair. (3,4) Bladder cancer is among the most frequent diagnosed cancer in the developed world.(5) Although development of bladder cancer is associated with exposure to tobacco and occupational exposure, (6) only a small proportion of exposed individuals will develop cancer, suggesting the involvement of genetic factors.DNA repair systems play an critical role in maintaining genomic integrity.(3) If DNA damage is unrepaired, mutations are propagated during subsequent cellular replication and ultimately result in activation of oncogenes or inactivation of tumor suppressor genes. So mutations on these genes which alter the function of these proteins may predispose an individual to cancer. Increasing molecular epidemiologic evidence has shown that polymorphisms in various DNA repair genes are associated with an increased risk of cancer. (7,8) The X-ray repair cross-complementing group 3 (XRCC3) belongs to a family of genes responsible for repairing DNA double strand breaks caused by normal metabolic processes and ⁄ or exposure to ionizing radiation. The XRCC3 is involved in homologous recombination repair (HRR) and chromosomal double-strand breaks repair processes, and it is necessary to maintain genomic integrity. It was demonstrated that cell lines defective in XRCC3 had a 25-fold decrease in homology directed repair of DNA double-strand breaks.(9) Shen et al.ide...

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ERCC1 haplotypes modify bladder cancer risk: A case–control study

Cited by 30 publications

References 40 publications

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese

XRCC1 and ERCC1 variants modify malignant mesothelioma risk: A case–control study

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

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