“…In addition, studies indicate that 40% of men with diabetes greater than 60 years of age have complete ED (7-15).Recent studies have reported that alteration of the cyclic guanosine monophosphate (cGMP)/nitric oxide (NO) pathway among men with diabetes with impaired vascular relaxation is related to endothelial dysfunction (16-18). Among men with diabetes, risk factors include increasing age, duration of diabetes, poor glycemic control, cigarette smoking, hypertension, dyslipidemia, androgen-deficiency states (19) and cardiovascular disease (CVD) (6,11,12,(20)(21)(22)(23)(24).ED as a marker of potential cardiovascular (CV) events has been reported by numerous investigators (25-34). In fact, ED has been shown to be significantly associated with all-cause mortality and CV events (35)(36)(37).…”