Erectile Dysfunction and Depression: A Systematic Review and Meta-Analysis

Liu, Qian; Zhang, Youpeng; Wang, Jin; Li, Sen; Cheng, Yongbiao; Guo, Jialun; Tang, Yong; Zeng, Hanqing; Zhu, Zhaohui

doi:10.1016/j.jsxm.2018.05.016

Cited by 142 publications

(117 citation statements)

References 56 publications

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“…The relatively high unemployment rate (99%) and increased odds of depression specifically found among US men within Cluster B differentiated it from similar clusters in other countries. Unemployment has been shown to negatively affect mental health, including depression, by up to 34%, and the incidence of ED is 1.39 times higher in patients with depression than in those without depression . Besides age, education, overweight/obese BMI and exercise frequency strongly predicted cluster membership in the IT population.…”

Section: Discussionmentioning

confidence: 99%

National Health and Wellness Survey exploratory cluster analysis of males 40‐70 years old focused on erectile dysfunction and associated risk factors across the USA, Italy, Brazil and China

et al. 2019

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Objectives: Prior studies of erectile dysfunction (ED) tend to narrowly focus on relationships with specific comorbidities, rather than evaluating a more comprehensive array of risk factors and assessing naturalistic patterns among them. This study identifies natural clusters of male characteristics from a general population sample per country, quantifies ED dynamics in these profiles and compares profiles across the US, Italy, Brazil and China samples. Methods: National Health and Wellness Survey 2015 and 2016 patient-reported data on men aged 40-70 years (USA n = 15,652; Italy n = 2,521; Brazil n = 2,822; China n = 5,553) were analysed. Hierarchical agglomerative clustering identified clusters where predictors included demographics, health characteristics/behaviours, ED risk factors and provider visits in the past 6 months. Multinomial logistic regression assessed the independent utility of variables in predicting cluster membership, compared with the healthiest control cluster per country.Results: Different natural clusters were found across countries, with four clusters for the USA, Italy and China and three clusters for Brazil. Age, income, employment, health behaviours and ED risk factors predicted different cluster membership across countries. In the USA, Italy and Brazil, younger clusters were predicted by ED, unhealthy behaviours and ED risk factors. Unique cluster profiles were identified in China, with ED and ED risk factors (aside from hypertension) not predicting cluster membership, while socio-demographics and health behaviours were strongly predictive.Conclusions: Natural cluster profiles revealed notable ED rates among adult males of age 40-70 in four different countries. Clusters were mainly predicted by unhealthy behaviours, ED risk factors and ED, regardless of level or presence of positive health characteristics and behaviours. This analysis identified meaningful subgroups of men with heightened ED risk factors, which can help healthcare providers to better recognise specific populations with the greatest need for intervention.Erectile dysfunction (ED) is characterised by the partial or total inability to consistently achieve and/or maintain an erection sufficient for satisfactory sexual intercourse. 1,2 ED can arise from organic (eg neurological damage, hormonal and vascular pathologies, medication side effects, systemic diseases) or psychogenic (eg poor mental health, performance anxiety, relationship problems) sources.However, it is typically because of a combination of these factors and remains a common disorder affecting men over 40 years old. 3,4 ED has a high global prevalence rate of 41% among men over the age of 18 years¸ and the Massachusetts Male Aging Study, the first large community-based observational survey, estimated ED prevalence to be even higher, 52%, in men aged 40-70 years. 5,6 ED prevalence also varies across countries, ranging from 17% in Italy to 34% in Japan, but the common finding central to all studies on ED prevalence is that ED increases with age, despite differenc...

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Section: Discussionmentioning

confidence: 99%

National Health and Wellness Survey exploratory cluster analysis of males 40‐70 years old focused on erectile dysfunction and associated risk factors across the USA, Italy, Brazil and China

et al. 2019

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“…This deformity of the erect penis is caused by formation of localized contracted fibrotic plaques, which may eventually progress towards calcified or ossified scars . This phenomenon can impair sexual intercourse, cause erectile dysfunction and be the source of significant emotional distress and issues in the relationship .…”

Section: Introductionmentioning

confidence: 99%

Simvastatin and the Rho‐kinase inhibitor Y‐27632 prevent myofibroblast transformation in Peyronie's disease‐derived fibroblasts via inhibition of YAP/TAZ nuclear translocation

et al. 2019

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ObjectivesTo uncover the anti-myofibroblast (MFB) properties of Rhokinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD), a sexually debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA). ConclusionTransformation of FBs into the contractile and extracellular matrix-producing MFBs occurs after TGF-b1 stimulation. In our experiments, Rho-kinase inhibition and simvastatin treatment were shown to prevent this in TGF-b1-stimulated cells on an RNA and protein level through the inhibition of YAP/TAZ nuclear translocation. Y-27632 and simvastatin could become a novel treatment option in the early treatment of PD.

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“…ED has been found to be more prevalent among aged population [4][5][6], smokers [7] and in population with comorbidities like diabetes mellitus [8][9][10], peripheral vascular disorders, coronary artery disease [11] and among individuals treated for hypertension [12]. Needles to say psychogenic illness like anxiety [13,14], depression [15,16] have also shown an impact on ED.…”

Section: Introductionmentioning

confidence: 99%

“…Erectile dysfunction has severe consequence on men's mental health like depression, anxiety and low self-esteem and these effects may even extend to their female companion [23]. It affects quality of life and sometimes it has been associated with common mental disorders [13][14][15][16]. The effects of ED maybe worse in developing countries setting like Tanzania because men's sexual health has been forgotten.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with erectile dysfunction among adult men in Moshi municipal, Tanzania: community-based study

Bosco

Mushi

Moshi

et al. 2020

Preprint

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Background: Erectile dysfunction (ED) has a negative impact on ones’ relationships with poor quality of life as inevitable result. Men’s sexual health has been forgotten in most developing countries and therefore the burden of ED and associated risk factors are not known in these settings. This study aimed to determine the prevalence and factors associated with erectile dysfunction among adult men in Moshi municipality, northern Tanzania. Methodology: A community based cross-sectional study was conducted in July 2019. Multi stage sampling technique was used to enroll men aged 18 years and above infour wards of Moshi municipality. The 5-item version of the International Index of Erectile Function (IIEF-5) scale was used to assess erectile dysfunction. Multivariate logistic regression was done to get factors associated with ED. Results: The mean age of the 381 men was 39.6 (SD ±16.8) years. Theoverall prevalence of ED on this study was 29.7%. The severity of ED among study participants was 13.4 % (51), 9.7 % (37), 3.7 % (14), 2.9% (11) participants had mild, mild to moderate, moderate and severe erectile dysfunction respectively. Age, tobacco use, overweight, hypertension and diabetes all showed significance association with ED. However, in multivariate logistic analysis only age ≥40 years and hypertension remain statistically significant associated with ED [(OR 5.2, 95% CI 2.68-10.21, P<0.001), (OR 11.5, 95% CI 5.8-22.76, P<0.001) and (OR 2.5, 95% CI 1.06-5.86, P=0.035) ] respectively. Conclusion: About one in three men in Moshi municipal had ED. High prevalence of ED among hypertensive individuals suggest a need to establish ED screening program during their routine clinic for early detection and treatment. Furthermore, education should be given on lifestyle modification to prevent hypertension and diabetes in the community. The outcome will be improvement of patient’s quality of life. Key words: Erectile dysfunction, Diabetes mellitus, Hypertension, Physical activities, Prevalence, Predictors, Tanzania

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Erectile Dysfunction and Depression: A Systematic Review and Meta-Analysis

Cited by 142 publications

References 56 publications

National Health and Wellness Survey exploratory cluster analysis of males 40‐70 years old focused on erectile dysfunction and associated risk factors across the USA, Italy, Brazil and China

National Health and Wellness Survey exploratory cluster analysis of males 40‐70 years old focused on erectile dysfunction and associated risk factors across the USA, Italy, Brazil and China

Simvastatin and the Rho‐kinase inhibitor Y‐27632 prevent myofibroblast transformation in Peyronie's disease‐derived fibroblasts via inhibition of YAP/TAZ nuclear translocation

Prevalence and factors associated with erectile dysfunction among adult men in Moshi municipal, Tanzania: community-based study

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