Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

Karkin, Kadir; Alma, Ergün

doi:10.4081/aiua.2021.4.460

Cited by 13 publications

(7 citation statements)

References 39 publications

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“…The results of this study represented that the levels of testosterone of patients before and after COVID-19 were significantly different. They also concluded that high testosterone levels increase the rate of hospitalization in the intensive care unit by intensifying the disease [17].…”

Section: Sex and Gender Aspects In Covid-19mentioning

confidence: 99%

Androgens’ Role in Severity and Mortality Rates of COVID-19

et al. 2022

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Background and Aim: by the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. this review aimed to assess the role of androgens in COVID-19 severity and mortality Discussion: androgens increase expression of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2) which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) was substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor drugs considerably modified COVID-19 symptoms. androgen deprivation therapy also improved COVID-19 symptoms in prostate cancer: overall the role of androgens in severity of COVID-19 and its associated mortality seemed to be very important . So more studies in variety of populations are required to define the absolute role of androgens.

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Section: Sex and Gender Aspects In Covid-19mentioning

confidence: 99%

Androgens’ Role in Severity and Mortality Rates of COVID-19

et al. 2022

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“…Karkin and Alma also revealed changes in endothelium, in corpus cavernosum biopsy, in patients who had developed COVID-19 [ 30 ]. Also, the testosterone level was significantly lower after COVID-19 infection [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Mental and Sexual Health of Men in Times of COVID-19 Lockdown

Szuster

Pawlikowska

Kostrzewska

et al. 2022

IJERPH

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Due to the worldwide spread of COVID-19, some restrictions were introduced which could lead to the development of distress and somatic symptoms. This survey aimed to study the mental and sexual health of men during the COVID-19 outbreak. An online questionnaire was conducted to collect data on contact with people suspected of infection/infected with the SARS-CoV-2 virus, use of stimulants, and perceived mental and sexual health during isolation among Polish men. They were also asked to answer the Beck Depression Inventory (BDI) and the International Index of Erectile Function (IIEF-15) questionnaire. In total, 606 men with a mean age of 28.46 ± 9.17 years took part in the survey. Fear of contracting the COVID-19 infection had a negative impact on the mental health of 132 men (21.8%). Fear of the health condition of loved ones caused stress and a depressed mood in 253 men (41.7%), and media reports worsened the mental health of 185 men (30.2%). In the BDI, 71.95% of the respondents did not suffer from depressive symptoms, 17.33% were diagnosed with mild depression, 6.11% with moderate depression, and 4.62% had severe depression. The mean score in the IIEF-15 questionnaire in the erectile function domain was 22.27, orgasm—7.63, desire—8.25, satisfaction—10.17, and general satisfaction—6.84. Depressive symptoms indicated more severe sexual functioning disorders (p < 0.001). Fear, following the media, and loneliness were associated with more severe depressive and sexual disorders (p < 0.001). The libido level (p = 0.002) and frequency of sexual activity (p < 0.001) were also lower during the pandemic than before the lockdown. These data showed that the COVID-19 pandemic had a significant impact on male mental and sexual health.

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“…Initial reports describing increased risk of ED after COVID-19 have been limited to small cohort studies (<75 COVID-positive men), but have shown reduction of International Index Erectile Function-5 (IIEF-5) scores after COVID-19 infection and increased rates of ED compared to age-matched controls [10,12,13]. Evaluation of corporal tissue months after COVID-19 infection revealed persistence of COVID-19 peplomers suggesting a possible pathophysiologic mechanism for ED [7].…”

Section: Introductionmentioning

confidence: 98%

Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction

et al. 2023

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We sought to assess if COVID-19 infection recovery is associated with increased rates of newly diagnosed erectile dysfunction. Using IBM MarketScan, a commercial claims database, men with prior COVID-19 infection were identified using ICD-10 diagnosis codes. Using this cohort along with an age-matched cohort of men without prior COVID-19 infection, we assessed the incidence of newly diagnosed erectile dysfunction. Covariates were assessed using a multivariable model to determine association of prior COVID-19 infection with newly diagnosed erectile dysfunction. 42,406 men experienced a COVID-19 infection between January 2020 and January 2021 of which 601 (1.42%) developed new onset erectile dysfunction within 6.5 months follow up. On multivariable analysis while controlling for diabetes, cardiovascular disease, smoking, obesity, hypogonadism, thromboembolism, and malignancy, prior COVID-19 infection was associated with increased risk of new onset erectile dysfunction (HR 1.27; 95% CI 1.1-1.5; P = 0.002). Prior to the widespread implementation of the COVID-19 vaccine, the incidence of newly diagnosed erectile dysfunction is higher in men with prior COVID-19 infection compared to age-matched controls. Prior COVID-19 infection was associated with a 27% increased likelihood of developing new-onset erectile dysfunction when compared to those without prior infection.

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Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

Cited by 13 publications

References 39 publications

Androgens’ Role in Severity and Mortality Rates of COVID-19

Androgens’ Role in Severity and Mortality Rates of COVID-19

Mental and Sexual Health of Men in Times of COVID-19 Lockdown

Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction

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