Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study

Abstract

Objective To define the incidence of erectile dysfunction (ED) in a population-based cohort of men with psoriatic arthritis (PsA). Methods Data pertaining to demographics, ED, and potential confounding diagnosis were extracted from a comprehensive medical record system for a population-based cohort of men with PsA and an age-matched male comparator cohort. Cumulative incidence of ED adjusted for competing risk of death was compared between the two cohorts. Results There were 128 age-matched pairs of men with PsA and without PsA in the described cohorts. At baseline there was a 7% prevalence of ED in men with PsA prior to diagnosis compared to a 3% prevalence of ED in the comparator cohort (p=0.16). After PsA diagnosis / index date, diagnosis with PsA was associated with an increased risk of ED (age-adjusted HR 1.45, 95%CI: 0.79-2.68), but this association did not reach statistical significance. This was based on 24 cases of ED in the men with PsA and 18 cases within the comparator cohort. No confounding factors or ED treatment strategies differed significantly between men with PsA and ED and comparators with ED. Conclusion Men with PsA may have an increased risk of ED, which was detected, but likely underpowered in this study. Whether this difference is secondary to higher prevalence of traditional risk factors of ED in men with PsA compared to general population will require further study.

Validation of Turkish Psoriatic Arthritis Screening Tool (TurPAS) for Psoriatic Arthritis: A Cross-sectional Comparative Study

“…In our study, when compared to the patients with and without PsA, only family history of PsA and CRP levels were different which were higher in patients with PsA than those without. These ndings were consistent with the literature (14) (15). No signi cant difference was observed in patients with and without PsA in terms of age, gender, PsO duration, presence of comorbidities, PASI score, PsO subtypes in patients with and without PsA in our study.…”

“…Higher TurPAS and EARP scores in patients with PsA than those without in our study were also expected ndings. In Lopez-Medina study, while polyarticular involvement was the dominant feature of PsA (60%), mono-oligoarthritis was observed in 40%, enthesitis in 45.8%, dactylitis in 37% and axial involvement in 35.5% in patients with PsA (15). In our study, although oligo-monoarticular subtype was the most frequent involvement, other manifestations were similar to the former study.…”

Sexuality and sexual dysfunction in patients with psoriatic arthritis: A cross-sectional study

“…In the literature on psoriasis, SD is more prevalent in women than in men [ 8 , 9 , 25 ], but we observed mild and relatively more frequent impairment in the male group with PsA. A cohort study found an increased risk of erectile dysfunction (ED) in men with PsA, but likely underpowered due to the small number of cases [ 26 ].…”

Inflammatory bowel disease is an independent risk factor for male erectile dysfunction

“…In their animal experiment, Carneiro et al [20] showed that rats developed endothelial dysfunction and cavernosal smooth muscle hypercontractility after infusion of TNF-α. Similarly, Wilton et al [21] reported an increase in proinflammatory cytokine gene expression (IL-1b, IL-6 and TNF-a) and macrophage infiltration in the major pelvic ganglion in a rat model in which they induced ED through bilateral cavernous nerve damage. In another study, it was revealed that overexpression of IL-6 and TNF-α in the corpus cavernosum tissue caused ED in Type 2 diabetic rats [22].…”