Erectile dysfunction severity as a predictor of left main and/or three-vessel disease in acute coronary syndrome patients

Al-Daydamony, Mohammad M.; Shawky, Ahmad; Tharwat, Ahmad

doi:10.1016/j.ihj.2018.05.006

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…They concluded that the angiographic severity of CAD was found to be more in patients with moderate or severe ED. 14 In conrast, in a study on male patients with type II diabetes and CAD, Gazzaruso et al. reported that ED was significantly more prevalent in type II diabetic males with CAD, however, they did not find a significant relationship between ED severity and CAD severity, and between IIEF-5 score and Gensini score.…”

Section: Discussionmentioning

confidence: 92%

“… 16 Previous studies have used the Gensini score as a sub-parameter, but for the first time, our study evaluated the relationship between Gensini score and ED severity. 13 , 14 , 15 In the study involving 85 patients with ACS, Al-Daydamony et al comparing patients with IIEF score ≥ 17 (mild or no ED) and patients with IIEF score < 17 (moderate or severe ED), they found patients with moderate or severe ED had significantly higher mean Gensini score. They concluded that the angiographic severity of CAD was found to be more in patients with moderate or severe ED.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship and correlation between Gensini score and IIEF-5 were evaluated for the first time in this study. 13 , 14 , 15 We aimed to evaluate the relationship between Gensini score and ED and also to reveal the relationship between the Gensini score and the severity of ED.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Gensini Score and Erectile Dysfunction in Patients with Chronic Coronary Syndrome

et al. 2021

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Introduction In previous studies, the relationship between atherosclerosis and erectile dysfunction (ED) was examined, but the relationship and correlation between Gensini score which evaluates the extent and severity of chronic coronary syndrome (CCS), and ED severity were not investigated. Aim To evaluate the relationship between Gensini score and ED in patients with CCS. Methods We included 142 consecutive male patients with the diagnosed CCS and underwent an elective coronary angiography between January 2019 and March 2020. Main Outcome Measure Correlation analysis demonstrated that Gensini score significantly negatively correlated with the International Index Erectile Function - 5 (IIEF-5) score ( r = -0.417, P < .001). Results Severe ED was present in 48 (33.8%) patients, moderate ED in 31 (21.8%) patients, and mild ED in 22 (15.5%) patients. 41(28.9%) patients did not have ED. Both the No ED and Mild ED groups were statistically significantly lower than the Severe ED group in terms of the Gensini score ( P < .05). When the recommended optimal cut-off point and accuracy measurements were made for the Gensini score, the area under curve (AUC) value in predicting ED was 0.806 (95% CI: 0.732-0.880, P < .001). Multivariate logistic regression analysis demonstrated that independent predictors for ED were Gensini score and age ( P < .001, and P = .026, respectively). Every 1 unit increase in Gensini score resulted in a 6% increase in the occurrence of ED (OR = 1.06, CI:1.03-1.10, P < .001). Conclusion ED can be caused by endothelial dysfunction. Patients with severe CSS and high Gensini score should be evaluted for ED. ED may be a sign of severe CCS and a high Gensini score. It is also necessary to evaluate cardiological in patients with ED. Deger M, Ozmen C, Akdogan N, et al. The Relationship Between Gensini Score and Erectile Dysfunction in Patients with Chronic Coronary Syndrome. Sex Med 2021;9:100376.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Gensini Score and Erectile Dysfunction in Patients with Chronic Coronary Syndrome

et al. 2021

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“…This predictor is additionally linked to the presence of severe coronary artery disease (Sanchez‐Nadales et al., 2023 ). Elderly patients exhibited a higher prevalence of severe and extensive coronary disease (Al‐Daydamony et al., 2018 ; D'Ascenzo et al., 2012 ; Salimi et al., 2023 ). This variable examined in our study was also identified as a predictor of LM/3VD with an SS greater than 22.…”

Section: Discussionmentioning

confidence: 99%

Early predictors of severe left main and/or three‐vessel disease in patients with non‐ST‐segment elevation myocardial infarction: A dual‐center retrospective study

Huang,

Han,

Huang

et al. 2024

Noninvasive Electrocardiol

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BackgroundEarly detection of patients concomitant with left main and/or three‐vessel disease (LM/3VD) and high SYNTAX score (SS) is crucial for determining the most effective revascularization options regarding the use of antiplatelet medications and prognosis risk stratification. However, there is a lack of study for predictors of LM/3VD with SS in patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). We aimed to identify potential factors that could predict LM/3VD with high SS (SS > 22) in patients with NSTEMI.MethodsThis dual‐center retrospective study included a total of 481 patients diagnosed with NSTEMI who performed coronary angiography procedures. Clinical factors on admission were collected. The patients were divided into non‐LM/3VD, Nonsevere LM/3VD (SS ≤ 22), and Severe LM/3VD (SS > 22) groups. To identify independent predictors, Univariate and logistic regression analyses were conducted on the clinical parameters.ResultsA total of 481 patients were included, with an average age of 60.9 years and 75.9% being male. Among these patients, 108 individuals had severe LM/3VD. Based on the findings of a multivariate logistic regression analysis, the extent of ST‐segment elevation observed in lead aVR (OR: 7.431, 95% CI: 3.862–14.301, p < .001) and age (OR: 1.050, 95% CI: 1.029–1.071, p < .001) were identified as independent predictors of severe LM/3VD.ConclusionThis study indicated that the age of patients and the extent of ST‐segment elevation observed in lead aVR on initial electrocardiogram were the independent predictive factors of LM/3VD with high SS in patients with NSTEMI.

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“…e risk of acute coronary syndrome (ACS) is evident in many of subjects with ED [33]. Extensive involvement of coronary arteries in terms of left main and three-vessel disease was reported in ACS patients who suffered from moderate or severe ED [34]. ED predicts poor outcome such as rehospitalization and death in patients with acute MI [35].…”

Section: Discussionmentioning

confidence: 99%

Detection of Coronary Artery Disease by an Erectile Dysfunction Questionnaire

Sayadi

Elmafshar

Razeghian‐Jahromi

et al. 2021

Cardiology Research and Practice

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Background. Erectile dysfunction (ED) has been become an important health challenge in recent years affecting the quality of life significantly. In addition to imposed social problems, it may warn the existence of cardiovascular diseases especially that of ischemic heart disease (IHD). We aimed to investigate the association between ED and coronary artery disease (CAD) in a population of patients with stable angina based on angiographic findings. Methods. In this cross-sectional study, among patients who are diagnosed with stable angina referring for coronary angiography (excluding those with acute coronary syndrome), 200 patients were selected. They were divided equally into two groups of case and control. The former were positively CAD patients and the latter were normal peers, with respect to angiographic results. International index of erectile function (IIEF) questionnaire was used in order to evaluate erectile function during recent four weeks. Statistical analyses of the t-test and logistic regression were performed. The significance level was considered as a P value less than 5%. Results. The age range of the patients was 40–65 years old. The case group was significantly older ( P = 0.001 ). There was a remarkable relation between the low score from IIEF (ED) and existence of CAD. Also, the severity of ED was in a close relationship with severity of CAD. In addition, dyslipidemia in terms of high LDL and low HDL was associated with both ED and severity of CAD. Conclusion. Other than CAD, ED could be considered as one of the manifestations of atherosclerosis. Accordingly, the IIEF questionnaire is a useful tool to early diagnosis of CAD. Also, IIEF-derived scores estimate CAD severity. We suggest subjects with low score of IIEF examine their cardiovascular health with special attention to possible existence of IHD.

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Erectile dysfunction severity as a predictor of left main and/or three-vessel disease in acute coronary syndrome patients

Cited by 10 publications

References 25 publications

The Relationship Between Gensini Score and Erectile Dysfunction in Patients with Chronic Coronary Syndrome

The Relationship Between Gensini Score and Erectile Dysfunction in Patients with Chronic Coronary Syndrome

Early predictors of severe left main and/or three‐vessel disease in patients with non‐ST‐segment elevation myocardial infarction: A dual‐center retrospective study

Detection of Coronary Artery Disease by an Erectile Dysfunction Questionnaire

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