Erectile Function in Cardiovascular Disease and Hypertension: the Role of Nebivolol

Manolis, Athanasios; Doumas, Michael

doi:10.4172/2167-1095.1000226

Cited by 7 publications

(3 citation statements)

References 68 publications

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“…[ 19 ] Nebivolol exhibits highly selective β1-AR blockade and has vasodilatory properties secondary to the enhancement of nitric oxide bioavailability. [ 20 ] Experimental data demonstrate that nebivolol results in increases in endothelial nitric oxide synthase activation and phosphorylation, and endothelium-dependent relaxation of the corpora cavernosa, [ 21 ] which exerts protective effects on erectile function against the disruptive effects of CPB in patients undergoing CABG.…”

Section: Discussionmentioning

confidence: 99%

The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery

Yang

Yong

et al. 2020

Medicine

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Background: Erectile dysfunction is a common disease. It affects the quality of life of both husband and wife and its prevalence is higher in patients with overt cardiovascular disease or cardiovascular risk factors. In recent years, multiple studies confirm that nebivolol exerts protective effects on erectile function against the disruptive effects of cardiopulmonary bypass in patients undergoing coronary artery bypass grafting, but its quality and efficacy have not been systematically evaluated. Therefore, it is necessary to carry out a systematic review and meta-analysis to fully evaluate the efficacy and safety of nebivolol on erectile function in the cases with coronary artery bypass grafting. Methods and analysis: Chinese and English literature of nebivolol on erectile function in the cases with coronary artery bypass surgery published before August 31, 2020 will be comprehensive searched in PubMed, Cochrane Library, EMBASE, WANFANG, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journal Database, Chinese biomedical document service system, and Clinicaltrials.gov. Only randomized controlled trials that meet the eligibility criteria will be included. Two researchers will independently complete literature screening, data extraction and assess the risk of bias, and the third investigator will handle disagreements. Our main evaluation includes 2 outcome indicators including the international index of erectile function 5 score and adverse events. RevMan 5.3 and Stata 14.0 will be used to conduct this systematic review. The preferred reporting items for systematic reviews and meta-analysis protocols (PRISMA-P) statement is followed in this protocol and the PRISMA statement will be followed in the completed systematic review. Conclusion and dissemination: The efficacy and safety of nebivolol on erectile function in the cases with coronary artery bypass grafting will be evaluated. We will publish the results of this systematic review in peer-reviewed journals to provide new evidence to clinicians. Ethics and dissemination: Ethical approval is not required as the review is a secondary study based on published literature. The results will be published in a public issue journal to provide evidence-based medical evidence for urologists and andrologists to make better clinical decisions. Registration information: INPLASY202060110.

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Section: Discussionmentioning

confidence: 99%

The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery

Yang

Yong

et al. 2020

Medicine

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“…Селективные β-АБ III поколения обладают сосудорасширяющим действием, вторичным по отношению к повышению биодоступности оксида азота [75]. Экспериментальные данные показали, что данная группа препаратов приводит к повышению активности эндотелиального оксида азота и ускорению фосфорилирования синтазы, а также к эндотелийзависимому снижению тонуса кавернозных тел.…”

Section: подходы к выбору гипотензивной терапииunclassified

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

et al. 2021

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Sexual health is an essential part of overall health, and an active and healthy sex life is an important aspect of a good quality of life. Cardiovascular diseases and sexual health disorders have common risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, obesity and smoking) and common pathogenesis (endothelial dysfunction, inflammation and atherosclerosis). All this led to speculations about the pathophysiology and treatment options for sexual dysfunctions. The use of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction (ED) in men. This article focuses on ED and its relationship with hypertension. This document was created by experts from the Russian Medical Society of Arterial Hypertension with the participation of a member of the European Society of Hypertension Working Group on Sexual Dysfunction and Arterial Hypertension. In recent years, the expert group was very active in educating hypertension specialists and related specialties physicians about ED via numerous lectures at national and international congresses. It has been noted that ED precedes the development of coronary heart disease. The artery diameter hypothesis has been proposed as a possible explanation for this observation. Clinical manifestations of atherosclerotic lesions and/or endothelial dysfunction of the penile arteries may precede those in larger arteries. Patients with hypertension who receive antihypertensive drugs are more likely to suffer from sexual dysfunctions compared to untreated patients. The occurrence of ED appears to be related to the undesirable effects of antihypertensive drugs on the penile tissues. There is information about various effects of antihypertensive drugs on erectile function.

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“…Beta blockers have been implicated in erectile dysfunction [49] but this effect has been found to be drug-specific other than class effect [50]. Decreased sympathetic outflow coupled with depression and loss of libido (reduced level of testosterone) are implicated in the pathophysiology of erectile dysfunction among hypertensive individuals on beta-blockers [49]. A recent survey, where 199 patients were followed-up after coronary artery bypass graft.…”

Section: Beta-blockers (Bb)mentioning

confidence: 99%

A Review on Erectile Dysfunction Among Hypertensive Patients on Pharmacotherapy

Boamah¹

2017

IJCEMS

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Hypertension and its related disorders have a high mortality as well as morbidity and require strict adherence to medications in order to mitigate these consequences. Sexual dysfunction is prevalent among patients with hypertension and can either be attributed to the disease progression or as a result of antihypertensive medications. Most patients report the symptoms after initiation therapy and sometimes leads to a spurious association with antihypertensive drugs. However, most drugs in the antihypertensive classes have been associated with sexual dysfunction in both men and women. The most implicated drugs are diuretics, beta-blockers, and centrally acting agents while angiotensin modulating drugs have proved to improve upon erectile dysfunction. The older generation of antihypertensive medications tends to have a negative impact on sexual performance. Females experience sexual dysfunction associated with hypertension and its treatment, but this is grossly under-reported compared to their male counterparts. The incidence in females is higher compared to men and it is sometimes erroneously considered as part of the post-menopausal period rather than hypertension. The impact of medications on sexual dysfunction has somewhat produced contrasting results with some studies showing an association with medications and others proving otherwise. Clinicians need to be aware of the impact of sexual dysfunction among hypertensive patients in order to make an informed decision regarding dosage and choice of medications while keeping target blood pressure in mind.

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Erectile Function in Cardiovascular Disease and Hypertension: the Role of Nebivolol

Cited by 7 publications

References 68 publications

The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery

The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

A Review on Erectile Dysfunction Among Hypertensive Patients on Pharmacotherapy

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