Erectile Function Outcomes after Robot‐Assisted Radical Prostatectomy: Is It Superior to Open Retropubic or Laparoscopic Approach?

Isgoren, A.E.; Saitz, Theodore R.; Şerefoğlu, Ege Can

doi:10.1002/smrj.21

Cited by 10 publications

(4 citation statements)

References 130 publications

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“…A significant amount of data have been reported, outlining various treatment outcomes in men operated with a variety of NS approaches. In terms of the effects of surgical interventions (eg, robot-assisted RP vs other types of surgery), data are still conflicting [3,[101][102][103][104][105]. Of note, despite the advancements in surgical techniques and the advent of minimally invasive approaches, the rates of post-RP ED are still high and ranging between 25% and 75% [3,[101][102][103][104][105].…”

Section: Risk Factors For Edmentioning

confidence: 99%

“…In terms of the effects of surgical interventions (eg, robot-assisted RP vs other types of surgery), data are still conflicting [3,[101][102][103][104][105]. Of note, despite the advancements in surgical techniques and the advent of minimally invasive approaches, the rates of post-RP ED are still high and ranging between 25% and 75% [3,[101][102][103][104][105]. Even nonsurgical treatments of PCa (ie, radiotherapy and brachytherapy) can be associated with significant impairment of erectile function [106,107].…”

Section: Risk Factors For Edmentioning

confidence: 99%

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European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

et al. 2021

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Section: Risk Factors For Edmentioning

confidence: 99%

Section: Risk Factors For Edmentioning

confidence: 99%

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

et al. 2021

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“…Surgical interventions to the prostate also have an impact on erectile function according to the type of surgery that was performed [45]. Epidemiologically, there are other risk factors that potentially associate to ED, including psoriasis [46][47][48], gouty arthritis [49,50], ankylosing spondylitis [51], nonalcoholic fatty liver [52], chronic liver disorders [53], chronic periodontitis [54], open-angle glaucoma [55], inflammatory bowel disease [56], and complications following transrectal ultrasound (TRUS) guided prostate biopsy [57].…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Lower Urinary Tract Symptoms (LUTS) and Sexual Function and Dysfunction

Konstantinidis¹,

Eleftheropoulos²,

Karafotias³

2020

Lower Urinary Tract Dysfunction - From Evidence to Clinical Practice

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In recent years, the coexistence of sexual dysfunction (SD) and lower urinary tract symptoms (LUTS) has become a popular topic for researchers. Numerous clinical epidemiologic studies have been planned for this reason and have evaluated the relationship between these seemingly irrelevant urological conditions. The connection between SD and LUTS has already been acknowledged, and common pathophysiological pathways have been recognized. In this chapter was attempted to evaluate the impact on patient's quality of life (QoL), common pathophysiological pathways and therapy aspects of this condition. SD and LUTS are common problems among the general population and affect a great percentage of urological patients. It is a subject that affects the community in social, financial, and psychological terms. In this case, research for new treatment options has been triggered as phosphodiesterase type 5 inhibitors established their role as the widely approved combination therapy.

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“…Radical prostatectomy (RP) is a widely performed treatment for localised prostate cancer with the spread of robot-assisted laparoscopic RP. However, postoperative erectile dysfunction (ED) with cavernous nerve (CN) injury is still a common adverse event that decreases patients' quality of life [1][2][3][4]. In order to improve ED after RP, nerve-sparing surgery has been attempted.…”

Section: Introductionmentioning

confidence: 99%

Intravenously engrafted human multilineage‐differentiating stress‐enduring (Muse) cells rescue erectile function after rat cavernous nerve injury

Koyama,

Yamashita,

Kato

et al. 2023

BJU International

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ObjectiveTo evaluate the effect of intravenous administration of human multilineage‐differentiating stress‐enduring (Muse) cells on rat postoperative erectile dysfunction (ED) with cavernous nerve (CN) injury without an immunosuppressant.Materials and MethodsMale Sprague–Dawley rats were randomised into three groups after CN crush injury. Either human‐Muse cells, non‐Muse mesenchymal stem cells (MSCs) (both 1.0 × 105 cells), or vehicle was infused intravenously at 3 h after CN injury without immunosuppressant. Erectile function was assessed by measuring intracavernous pressure (ICP) and arterial pressure (AP) during pelvic nerve electrostimulation 28 days after surgery. At 48 h and 28 days after intravenous infusion of Muse cells, the homing of Muse cells and non‐Muse MSCs was evaluated in the major pelvic ganglion (MPG) after CN injury. In addition, expressions of C‐X‐C motif chemokine ligand (Cxcl12) and glial cell line‐derived neurotrophic factor (Gdnf) in the MPG were examined by real‐time polymerase chain reaction. Statistical analyses and comparisons among groups were performed using one‐way analysis of variance followed by the Tukey test for parametric data and Kruskal–Wallis test followed by the Dunn–Bonferroni test for non‐parametric data.ResultsThe mean (SEM) ICP/AP values at 28 days were 0.51 (0.02) in the Muse cell group, 0.37 (0.03) in the non‐Muse MSC group, and 0.36 (0.04) in the vehicle group, showing a significant positive response in the Muse cell group compared with the non‐Muse and vehicle groups (P = 0.013 and P = 0.010, respectively). In the MPG, Muse cells were observed to be engrafted at 48 h and expressed Schwann cell markers S100 (~46%) and glial fibrillary acidic protein (~24%) at 28 days, while non‐Muse MSCs were basically not engrafted at 48 h. Higher gene expression of Cxcl12 (P = 0.048) and Gdnf (P = 0.040) was found in the MPG of the Muse group than in the vehicle group 48 h after infusion.ConclusionIntravenously engrafted human Muse cells recovered rat erectile function after CN injury in a rat model possibly by upregulating Cxcl12 and Gdnf.

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Erectile Function Outcomes after Robot‐Assisted Radical Prostatectomy: Is It Superior to Open Retropubic or Laparoscopic Approach?

Cited by 10 publications

References 130 publications

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

Lower Urinary Tract Symptoms (LUTS) and Sexual Function and Dysfunction

Intravenously engrafted human multilineage‐differentiating stress‐enduring (Muse) cells rescue erectile function after rat cavernous nerve injury

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